000 04092nam a22004335i 4500
001 978-1-4614-5647-6
003 DE-He213
005 20140220082821.0
007 cr nn 008mamaa
008 121116s2013 xxu| s |||| 0|eng d
020 _a9781461456476
_9978-1-4614-5647-6
024 7 _a10.1007/978-1-4614-5647-6
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aAhmad, Aamir.
_eeditor.
245 1 0 _aBreast Cancer Metastasis and Drug Resistance
_h[electronic resource] :
_bProgress and Prospects /
_cedited by Aamir Ahmad.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aXI, 413 p. 59 illus., 45 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPreface -- Breast Cancer Statistics -- Epidemiology of Breast Cancer in Women -- The Complexities of Racial Disparity in Breast Cancer -- Major signaling pathways involved in Breast Cancer -- Breast Cancer Heterogeneity in Primary and Metastatic Disease -- Understanding Triple-negative Breast Cancer -- The biology of the deadly love connection between obesity, diabetes and breast cancer -- Progression of Early Breast Cancer to an Invasive Phenotype -- Pre-clinical modeling of breast cancer – which model to choose? -- Modeling breast cancer progression in 4-D -- Bone Metastasis of Breast Cancer -- Cellular and Molecular Mechanisms Involved in Breaching of The Blood-Brian Barrier By Circulating Breast Cancer Cells -- Resistance to Anthracyclines and Taxanes in Breast cancer -- Understanding of Tamoxifen Resistance of Breast Cancer based on Integrative Bioinformatics Approaches -- Current understanding of drug resistance mechanisms and therapeutic targets in HER2 overexpressing breast cancers -- Platinum and ruthenium complexes for the therapy of breast cancer diseases.-Development of Notch Pathway Inhibitors for Cancer Therapy -- Systems Biology Approaches in Breast Cancer Studies -- Epigenetic Factors in Breast Cancer Progression -- Breast Cancer Stem Cells and miRNAs -- Breast Cancer Stem Cells: responsible for therapeutic resistance and relapse? -- MicroRNAs in Breast Cancer Research: Progress and Promise -- Index.
520 _aThis comprehensive book on breast cancer brings together some of the leading experts in an attempt to better understand breast cancer disease, the factors that make it lethal and current research progress, integrating both basic research with clinical implications. This volume covers the following core issues: i) heterogeneity in breast cancer – statistics, epidemiology, breast cancer subtypes, racial disparity and the associated challenges, ii) available and upcoming model systems in breast cancer research, iii) breast cancer metastasis to bones and brain, iv) drug resistance mechanisms in breast cancer against targeted therapies and v) recent developments in breast cancer research – state of current research directions / technologies / approaches. With its comprehensive coverage of topics related to breast cancer, this volume is expected to have a very wide appeal. It serves as an excellent source of reference for students/beginning researchers just setting foot in the field and interested in getting to know all the aspects of this disease. The book should also appeal to advanced and senior researchers by bringing everyone up-to-date with the most current knowledge on various breast cancer topics of utmost relevance
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aDrug interactions.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aDrug Resistance.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461456469
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-5647-6
912 _aZDB-2-SBL
999 _c95467
_d95467