000 03199nam a22005055i 4500
001 978-1-4614-5532-5
003 DE-He213
005 20140220082820.0
007 cr nn 008mamaa
008 120930s2013 xxu| s |||| 0|eng d
020 _a9781461455325
_9978-1-4614-5532-5
024 7 _a10.1007/978-1-4614-5532-5
_2doi
050 4 _aQH588.S83
072 7 _aPSAK
_2bicssc
072 7 _aSCI017000
_2bisacsh
072 7 _aSCI049000
_2bisacsh
082 0 4 _a571.6
_223
100 1 _aBrevini, Tiziana A.L.
_eauthor.
245 1 0 _aGametogenesis, Early Embryo Development and Stem Cell Derivation
_h[electronic resource] /
_cby Tiziana A.L. Brevini, Georgia Pennarossa.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aXI, 66 p. 48 illus., 16 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSpringerBriefs in Stem Cells,
_x2192-8118
505 0 _aGametogenesis: Primordial germ cells; Mitosis and Meiosis; Maturation of the female gamete; Imprinting and epigenetic regulation; Fertilization; Oocyte activation -- Early embryo development: Syngamy and spindle formation; Cleavage, compaction and blastulation; Cell commitment and Waddington model of epigenetic restriction.  Asymmetric imprinting; Establishment of the body axis -- Stem cells and gametogenesis: Oocyte competence and potency; Oocyte as a source of uniparental pluripotent cells; Spindles of uniparental origin in mammals; Stem cells as a source of oocytes.
520 _aThis Brief offers a concise, handy overview of the main concepts related to Embryology, revisited through the novel concepts that are applied daily in stem cell research and cell therapy oriented investigations. It is based on three main areas:   -The process involved in female gamete differentiation and maturation. The main aspects related to cell biology will be covered and an overview of the epigenetic regulation of gametogenesis will be presented.   -Early stages of embryo development with a careful analysis of the regulatory mechanisms driving cleavage, polarization and genome activation. -Stem cell and gametogenesis. The use of the oocyte as a possible source for the derivation of stem cell lines is discussed and depicted as a powerful tool to investigate oocyte potency and asymmetric imprinting. The potential biological  implications are evaluated and use of stem cells to derive oocytes is presented. 
650 0 _aLife sciences.
650 0 _aReproductive Medicine.
650 0 _aCytology.
650 0 _aStem cells.
650 1 4 _aLife Sciences.
650 2 4 _aStem Cells.
650 2 4 _aReproductive Medicine.
650 2 4 _aCell Biology.
700 1 _aPennarossa, Georgia.
_eauthor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461455318
830 0 _aSpringerBriefs in Stem Cells,
_x2192-8118
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-5532-5
912 _aZDB-2-SBL
999 _c95436
_d95436