000			02858nam a22004455i 4500
001			978-1-4614-5260-7
003			DE-He213
005			20140220082819.0
007			cr nn 008mamaa
008			121206s2013 xxu| s |||| 0|eng d
020			_a9781461452607 _9978-1-4614-5260-7
024	7		_a10.1007/978-1-4614-5260-7 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
100	1		_aMunshi, Nikhil C. _eeditor.
245	1	0	_aAdvances in Biology and Therapy of Multiple Myeloma _h[electronic resource] : _bVolume 2: Translational and Clinical Research / _cedited by Nikhil C. Munshi, Kenneth C. Anderson.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013.
300			_aX, 287 p. 7 illus., 5 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aT cell responses in myeloma -- Novel antigenic targets for immunotherapy in myeloma -- Antibody-based therapies in Multiple Myeloma -- Defining multiple myeloma as a target for DNA gene fusion vaccines -- Harnessing allogeneic immunity for anti-myeloma response -- Dendritic cell and peptide-based vaccination in myeloma -- New Proteasome inhibitors -- Newer Imids -- New agents in myeloma -- Early Combination Studies in MM -- The effect of novel antimyeloma agents on bone metabolism -- Index.
520			_aDespite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients.   This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aToxicology.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aPharmacology/Toxicology.
700	1		_aAnderson, Kenneth C. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461452591
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-5260-7
912			_aZDB-2-SBL
999			_c95363 _d95363