000			03388nam a22005175i 4500
001			978-1-4614-5107-5
003			DE-He213
005			20140220082818.0
007			cr nn 008mamaa
008			121207s2013 xxu| s |||| 0|eng d
020			_a9781461451075 _9978-1-4614-5107-5
024	7		_a10.1007/978-1-4614-5107-5 _2doi
050		4	_aRB155-155.8
050		4	_aQH431
072		7	_aMFN _2bicssc
072		7	_aMED107000 _2bisacsh
082	0	4	_a611.01816 _223
082	0	4	_a599.935 _223
100	1		_aChan, Edward K. L. _eeditor.
245	1	0	_aTen Years of Progress in GW/P Body Research _h[electronic resource] / _cedited by Edward K. L. Chan, Marvin J. Fritzler.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013.
300			_aXI, 276 p. 47 illus., 25 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v768
505	0		_aPreface -- The GW body Story as an Example of Autoantibodies with Significant Impacts to Molecular Cell Biology -- The Discovery of GW Bodies -- The Discovery and Analysis of P Bodies -- Autoantibodies to Argonaute 2 (Su antigen) -- GW/P Bodies and Autoimmune Disease -- Function of GW182 and GW Bodies in siRNA and miRNA Pathways -- Post-Transcriptional Stimulation of Gene Expression by MicroRNAs -- Gawky (Gw) is the Drosophila Melanogaster GW182 Homologue -- The Role of GW182 Proteins in miRNA-mediated Gene Silencing -- Quantifying Argonaute Proteins in and out of GW/P-bodies: Implications in microRNA Activities -- Deadenylation and P-bodies -- Relationship of GW/P-bodies with Stress Granules -- Relationship of other Cytoplasmic Ribonucleoprotein (RNP) Bodies to GW/P Bodies -- A SNP in the Trinucleotide Repeat Region of the TNRC6A Gene Maps to a Major TNGW1 Autoepitope in Patients with Autoantibodies to GW182 -- Reflections on Ten Years of History of, and Future Prospects for, GW182 and GW/P Body Research -- Index.
520			_aGW bodies are novel cytoplasmic foci that were discovered and named by Dr. Chan’s group in 2002. These bodies are now known to be active cytoplasmic foci involved with the new gene regulation process mediated by microRNA that leads to translational repression and mRNA degradation. The detailed biological functions of these cytoplasmic structures are still being uncovered and the idea for this book is to provide the history of the discovery and the major work from different laboratories that has led to the characterization and elucidation of the structure and function of these new multiple subcellular structures.
650		0	_aMedicine.
650		0	_aHuman genetics.
650		0	_aBiochemistry.
650		0	_aCytology.
650	1	4	_aBiomedicine.
650	2	4	_aHuman Genetics.
650	2	4	_aCell Biology.
650	2	4	_aBiochemistry, general.
700	1		_aFritzler, Marvin J. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461451068
830		0	_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v768
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-5107-5
912			_aZDB-2-SBL
999			_c95315 _d95315