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003 DE-He213
005 20140220082818.0
007 cr nn 008mamaa
008 121207s2013 xxu| s |||| 0|eng d
020 _a9781461450702
_9978-1-4614-5070-2
024 7 _a10.1007/978-1-4614-5070-2
_2doi
050 4 _aQR180-189.5
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
082 0 4 _a616.079
_223
100 1 _aFlower, Darren R.
_eeditor.
245 1 0 _aImmunomic Discovery of Adjuvants and Candidate Subunit Vaccines
_h[electronic resource] /
_cedited by Darren R. Flower, Yvonne Perrie.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aX, 314 p. 51 illus., 34 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aImmunomics Reviews:, An Official Publication of the International Immunomics Society ;
_v5
505 0 _aIntroduction -- Bacterial genomes and vaccine design -- Identification of candidate vaccine antigens in silico -- Post-Genomic Antigen Discovery: Bioinformatical Approaches to Reveal Novel T-Cell Antigens of Mycobacterium Bovis -- Genome-based Computational Vaccine Discovery by Reverse Vaccinology -- Computational prediction of protein subcellular localization, genomic islands, and virulence to aid antigen discovery -- On the development of Vaccine Antigen Databases: Progress, Opportunity, and Challenge -- What have Dendritic Cells ever done for adjuvant design?  Cellular and Molecular Methods for the Rational Development of Vaccine Adjuvants -- Towards the Rational Discovery of Adjuvants -- Designing liposomes as vaccine adjuvants -- Enhancing the delivery and potency of antigens using non-ionic based vesicles -- Immune stimulating complexes (ISCOMs) and Quil-A containing particulate formulations as vaccine delivery systems -- Formulation and characterisation of PLGA microspheres as vaccine adjuvants -- Powder Vaccines for Pulmonary Delivery.
520 _aVaccine discovery is one of the most exciting and fast-moving areas of applied science. Since Edward Jenner’s work in the 18th century, vaccines have transformed health across the globe. Bringing together clinical, experimental, and computational disciplines vaccinology addresses the most pressing needs of 21st century health-care: the great infectious diseases threatening the developing world, such as HIV, Malaria, and TB; and chronic diseases, such as dementia, threatening the developed world. This volume seeks to expand the horizons of vaccine design and discovery by highlighting cutting edge work in three areas of vaccinology: the rational discovery of subunit vaccines, the identification of adjuvants, and the delivery of vaccines via state-of-the-art nanotechnology.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aVaccines.
650 0 _aToxicology.
650 0 _aBioinformatics.
650 1 4 _aBiomedicine.
650 2 4 _aImmunology.
650 2 4 _aBioinformatics.
650 2 4 _aVaccine.
650 2 4 _aPharmacology/Toxicology.
700 1 _aPerrie, Yvonne.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461450696
830 0 _aImmunomics Reviews:, An Official Publication of the International Immunomics Society ;
_v5
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-5070-2
912 _aZDB-2-SBL
999 _c95304
_d95304