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001 978-1-4614-5037-5
003 DE-He213
005 20140220082818.0
007 cr nn 008mamaa
008 121117s2013 xxu| s |||| 0|eng d
020 _a9781461450375
_9978-1-4614-5037-5
024 7 _a10.1007/978-1-4614-5037-5
_2doi
050 4 _aRB155-155.8
050 4 _aQH431
072 7 _aMFN
_2bicssc
072 7 _aMED107000
_2bisacsh
082 0 4 _a611.01816
_223
082 0 4 _a599.935
_223
100 1 _aSpies, Maria.
_eeditor.
245 1 0 _aDNA Helicases and DNA Motor Proteins
_h[electronic resource] /
_cedited by Maria Spies.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aXII, 299 p. 69 illus., 58 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v973
505 0 _aPreface -- Overview: What are DNA helicases? -- Structure and mechanisms of SF1 DNA helicases -- Structure and mechanisms of SF2 DNA helicases -- Structure and mechanisms of hexameric helicases -- Helicases at the replication fork -- DNA helicases associated with genetic instability, cancer and aging -- The Helicase-primase complex as a target for effective herpesvirus antivirals -- RecQ helicases - conserved guardians of genetic integrity -- Roles of DNA helicases in the mediation and rRegulation of homologous recombination -- DNA helicases in NER, BER and MMR -- Roles for helicases as ATP-dependent molecular switches -- The FtsK family of DNA pumps -- ATP dependent chromatin remodelers -- Index.
520 _aIn recent years, a number of groundbreaking structural and mechanistic studies deepened our understanding of helicase mechanisms and established new approaches for their analyses. Many fundamental mechanistic questions ranging from the mechanism of force generation, mechanochemical coupling to distinct mechanisms by which the same enzyme translocates on DNA removing obstacles, unwinds DNA and/or remodels nucleoprotein complexes, however, remain to be answered. It is even less understood how the helicase motors are incorporated into a wide range of genome maintenance and repair machines. The field has reached a stage when the studies of molecular mechanisms and basic biology of helicases can and shall be integrated with the studies of development, cancer and longevity. The objective of this book is to provide the first systematic overview of structure, function and regulation of DNA helicases and related molecular motors. By integrating the knowledge obtained through the diverse technical approaches ranging from single-molecule biophysics to cellular and molecular biological studies the editors aim to provide a unified view on how helicases function in the cell, are regulated in response to different cellular stresses and are integrated into large macromolecular assemblies to form a complex and adaptive living system.
650 0 _aMedicine.
650 0 _aHuman genetics.
650 0 _aBiochemistry.
650 0 _aCytology.
650 1 4 _aBiomedicine.
650 2 4 _aHuman Genetics.
650 2 4 _aBiochemistry, general.
650 2 4 _aCell Biology.
650 2 4 _aBiomedicine general.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461450368
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v973
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-5037-5
912 _aZDB-2-SBL
999 _c95293
_d95293