000 02928nam a22004815i 4500
001 978-1-4614-4966-9
003 DE-He213
005 20140220082817.0
007 cr nn 008mamaa
008 121206s2013 xxu| s |||| 0|eng d
020 _a9781461449669
_9978-1-4614-4966-9
024 7 _a10.1007/978-1-4614-4966-9
_2doi
050 4 _aQH301-705
072 7 _aPSA
_2bicssc
072 7 _aSCI086000
_2bisacsh
072 7 _aSCI064000
_2bisacsh
082 0 4 _a570
_223
100 1 _aMcFadden, Johnjoe.
_eeditor.
245 1 0 _aSystems Biology of Tuberculosis
_h[electronic resource] /
_cedited by Johnjoe McFadden, Dany J.V. Beste, Andrzej M. Kierzek.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aXV, 226 p. 33 illus., 28 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aForeword -- Modeling Mycobacterium tuberculosis H37Rv in silico -- Software Platform for Metabolic Network Reconstruction of Mycobacterium tuberculosis -- Probing Gene Regulatory Networks to Decipher Host-Pathogen Interactions -- Metabolism of Mycobacterium tuberculosis -- Protein-protein interaction in the –omics era: Understanding Mycobacterium tuberculosis function -- A systems biology approach for understanding granuloma formation and function in tuberculosis -- Stochastic gene expression in bacterial pathogens: a mechanism for persistence? -- Drug Discovery -- Diagnosis -- Index.
520 _aTuberculosis remains one of the world’s biggest killers responsible for more than a million deaths each year. New drugs and new vaccines are urgently needed to tackle the disease. This book describes the application of this century’s first new science, systems biology, to the study of tuberculosis. After introducing the basic principles of systems biology, successive chapters describe how systems-based approaches provide new insights into gene regulation, metabolism, protein-protein interaction, host-pathogen interactions, the immune response, persistence, drug treatment and diagnosis of tuberculosis. This book will be an invaluable aid to anyone interested in exploring how the latest science is helping us to understand this ancient disease.
650 0 _aLife sciences.
650 0 _aMicrobiology.
650 0 _aBiological models.
650 1 4 _aLife Sciences.
650 2 4 _aSystems Biology.
650 2 4 _aMicrobiology.
650 2 4 _aMedical Microbiology.
700 1 _aBeste, Dany J.V.
_eeditor.
700 1 _aKierzek, Andrzej M.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461449652
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-4966-9
912 _aZDB-2-SBL
999 _c95271
_d95271