000 03776nam a22004695i 4500
001 978-1-4614-4921-8
003 DE-He213
005 20140220082817.0
007 cr nn 008mamaa
008 121116s2013 xxu| s |||| 0|eng d
020 _a9781461449218
_9978-1-4614-4921-8
024 7 _a10.1007/978-1-4614-4921-8
_2doi
050 4 _aQD431-431.7
072 7 _aPSBC
_2bicssc
072 7 _aSCI007000
_2bisacsh
082 0 4 _a572.6
_223
100 1 _aOberhauser, Andres F.
_eeditor.
245 1 0 _aSingle-molecule Studies of Proteins
_h[electronic resource] /
_cedited by Andres F. Oberhauser.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aXIII, 274 p. 85 illus., 73 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aBiophysics for the Life Sciences ;
_v2
505 0 _aNanomechanics of proteins, both folded and disordered -- Force Spectroscopy and Recognition Imaging of Cells from the Immune System -- Catch bonds of integrin/ligand interactions -- AFM visualization of protein-DNA interactions -- Nano-visualization of proteins in action using high-speed AFM -- Enzyme catalysis at the single-molecule level.- Single-molecule studies of amyloidogenic proteins -- Stretching and Imaging Individual Proteins on Live Cells using Atomic Force Microscopy.- Individual proteins under mechanical stress: Lessons from theory and computer simulations.
520 _aSingle-molecule measurement techniques are providing fundamental information on the structure and function of biomolecules and are becoming an indispensable tool to understand how proteins work. During the last two decades, this field has grown at an almost exponential rate in terms of biological and biophysical applications. Single-molecule techniques have opened new fields of science that are at the crossroads of several disciplines such as biology, physics, chemistry, material science and computer science. These methods are often the approach of choice to clarify and better understand the structure and function of single proteins. This volume consists of up-to-date and comprehensive reviews of important and timely applications of different biological problems tackled by single-molecule methods; it also covers basic principles of operation, experiment and theory. In Single-molecule Studies of Proteins, expert researchers discuss the successful application of single-molecule techniques to a wide range of biological events, such as the imaging and mapping of cell surface receptors, the analysis of the unfolding and folding pathways of single proteins, the analysis interaction forces between biomolecules, the study of enzyme catalysis or the visualization of molecular motors in action. The chapters are aimed at established investigators and post-doctoral researchers in the life sciences wanting to pursue research in the various areas in which single-molecule approaches are important; this volume also remains accessible to advanced graduate students seeking similar research goals.
650 0 _aLife sciences.
650 0 _aBiochemistry.
650 1 4 _aLife Sciences.
650 2 4 _aProtein Science.
650 2 4 _aBiophysics and Biological Physics.
650 2 4 _aSingle Molecule Studies, Molecular Motors.
650 2 4 _aBiochemistry, general.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461449201
830 0 _aBiophysics for the Life Sciences ;
_v2
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-4921-8
912 _aZDB-2-SBL
999 _c95258
_d95258