000 03152nam a22004455i 4500
001 978-1-4614-4887-7
003 DE-He213
005 20140220082817.0
007 cr nn 008mamaa
008 121026s2013 xxu| s |||| 0|eng d
020 _a9781461448877
_9978-1-4614-4887-7
024 7 _a10.1007/978-1-4614-4887-7
_2doi
050 4 _aRC681-688.2
072 7 _aMJD
_2bicssc
072 7 _aMED010000
_2bisacsh
082 0 4 _a616.12
_223
100 1 _aTomanek, Robert J.
_eauthor.
245 1 0 _aCoronary Vasculature
_h[electronic resource] :
_bDevelopment, Structure-Function, and Adaptations /
_cby Robert J. Tomanek.
264 1 _aBoston, MA :
_bSpringer US :
_bImprint: Springer,
_c2013.
300 _aXVIII, 276 p. 74 illus., 59 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aGeneral concepts of blood vessel formation and remodeling -- Prenatal coronary morphogenesis -- Postnatal coronary morphogenesis and growth -- Structure-function of the coronary hierarchy -- Historical perspectives -- Coronary anomalies -- Aging -- Adaptations to exercise training -- Hypoxia -- Myocardial ischemia and infarction -- Cardiac hypertrophy -- Therapy for coronary circulation.
520 _aIschemic heart disease is the leading cause of morbidity and mortality in the developed world. The high metabolism and oxygen demand of the cardiac myocardium depends on both a high blood flow and a rich capillary density. For this reason, the growth of the coronary vasculature is vital, not only in early development, but also in the adult faced with various stresses. Novel technologies have enabled the discovery of the molecular mechanisms underlying the growth and assembly coronary vessels, and this volume covers the hierarchy of the coronary vasculature from its embryonic origins through its postnatal growth, adulthood, and senescence. Chapters address normal coronary development, coronary anomalies and their possible underlying developmental errors, coronary vessel adaptations to exercise training, aging, hypoxia, myocardial ischemia, and cardiac hypertrophy. This comprehensive overview of current research in coronary vessels and myocardial perfusion was written by Dr. Robert J. Tomanek, Emeritus Professor of Anatomy and Cell Biology at the University of Iowa. The book reviews, discusses, and integrates findings from various areas of coronary vasculature research, and as a result, will be a valuable reference source for cardiovascular scientists and physicians for many years to come.
650 0 _aMedicine.
650 0 _aCardiology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aCardiology.
650 2 4 _aMedicine/Public Health, general.
650 2 4 _aBiomedicine general.
650 2 4 _aMolecular Medicine.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461448860
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-4887-7
912 _aZDB-2-SME
999 _c95250
_d95250