000 03537nam a22004455i 4500
001 978-1-4614-4884-6
003 DE-He213
005 20140220082817.0
007 cr nn 008mamaa
008 121116s2013 xxu| s |||| 0|eng d
020 _a9781461448846
_9978-1-4614-4884-6
024 7 _a10.1007/978-1-4614-4884-6
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aRusso, Jose.
_eauthor.
245 1 0 _aRole of the Transcriptome in Breast Cancer Prevention
_h[electronic resource] /
_cby Jose Russo, Irma H. Russo.
264 1 _aBoston, MA :
_bSpringer US :
_bImprint: Springer,
_c2013.
300 _aXIII, 453 p. 135 illus., 121 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPreface -- The epidemiology of breast cancer and the basis for prevention -- In vivo model for breast cancer prevention -- Comparative effects of the preventive effect of pregnancy, steroidal hormones and hCG in the transcriptomic profile of the rat mammary gland -- The use of in vitro three-dimensional system for testing preventing agents -- Methodological approach fro studying the human breast -- The transcriptoma of breast cancer prevention -- Chromatin remodeling and pregnancy induced differentiation -- The role of spliceosome in the human breast -- Non coding RNAs and breast cancer prevention -- The role of stem cell in breast cancer prevention -- Index.
520 _aThis book is designed for advanced students and researchers in cell biology, biochemistry, molecular biology, medicine in general, and cancer in particular. It provides the latest data on the transcriptome of the mammary gland in order to establish the molecular and cellular biology of differentiation leading to cancer prevention. The authors have based their work on the epidemiological evidence that early first full term pregnancy is a protective factor in humans against breast cancer and using this knowledge have developed in vivo and in vitro experimental systems that have demonstrated mechanistically how the differentiation takes place.  The transcriptoma analysis of the female breast shows that an early first full term pregnancy reprograms the organ by imprinting a genomic signature that differs according to reproductive history.  This reprogramming takes place at the chromatin level by changing the transcriptional process. The modification of the transcriptional control is due to the expression of non-coding RNA sequences and post-transcriptional control driven by the spliceosome. The plasticity of the genome of the human breast makes possible this reprogramming that is not only induced by the physiological process of pregnancy but by the use of hormones mimicking pregnancy. The role of stem cells and their reprogramming during differentiation are presented as a new paradigm in breast cancer prevention.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aToxicology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aPharmacology/Toxicology.
700 1 _aRusso, Irma H.
_eauthor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461448839
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-4884-6
912 _aZDB-2-SBL
999 _c95249
_d95249