000			03381nam a22004575i 4500
001			978-1-4614-4815-0
003			DE-He213
005			20140220082816.0
007			cr nn 008mamaa
008			120913s2013 xxu| s |||| 0|eng d
020			_a9781461448150 _9978-1-4614-4815-0
024	7		_a10.1007/978-1-4614-4815-0 _2doi
050		4	_aRS380
050		4	_aRS190-210
072		7	_aTDCW _2bicssc
072		7	_aMED072000 _2bisacsh
082	0	4	_a615.19 _223
100	1		_aMüller, Markus. _eeditor.
245	1	0	_aMicrodialysis in Drug Development _h[electronic resource] / _cedited by Markus Müller.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013.
300			_aXI, 338 p. 55 illus., 29 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAAPS Advances in the Pharmaceutical Sciences Series, _x2210-7371 ; _v4
505	0		_aIntroduction to the Microdialysis Technology -- Recovery and Calibration Techniques: Toward Quantitative Microdialysis -- Analytical Considerations for Microdialysis Sampling -- Regulatory Aspects of Microdialysis: A United States Food & Drug Administration Perspective -- Microdialysis in CNS PKPD Research: Unraveling Unbound Concentrations -- Microdialysis in Antibiotic Research -- Skin and Transdermal Drug Delivery: Advantages and Challenges -- Translational Approaches For Predicting CNS Drug Effects Using Microdialysis -- Extracellular Amyloid-β Protein Dynamics in Alzheimer's Disease -- Microdialysis in Pain Research -- Microdialysis in Ocular Drug Development -- Microdialysis in Metabolic Research -- High Molecular Weight Targets and Treatments Using Microdialysis -- Complementary Techniques – Positron Emission Tomography -- Open Flow Microperfusion: An Alternative Method to Microdialysis? -- Microdialysis in Internal Organs and Tumors.
520			_aIn vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970ies, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development.
650		0	_aMedicine.
650		0	_aPharmaceutical technology.
650	1	4	_aBiomedicine.
650	2	4	_aPharmaceutical Sciences/Technology.
650	2	4	_aBiomedicine general.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461448143
830		0	_aAAPS Advances in the Pharmaceutical Sciences Series, _x2210-7371 ; _v4
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-4815-0
912			_aZDB-2-SBL
999			_c95229 _d95229