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001 978-1-4614-4744-3
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008 121026s2013 xxu| s |||| 0|eng d
020 _a9781461447443
_9978-1-4614-4744-3
024 7 _a10.1007/978-1-4614-4744-3
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aHoward, Kenneth A.
_eeditor.
245 1 0 _aRNA Interference from Biology to Therapeutics
_h[electronic resource] /
_cedited by Kenneth A. Howard.
264 1 _aBoston, MA :
_bSpringer US :
_bImprint: Springer,
_c2013.
300 _aXV, 337 p. 46 illus., 35 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Delivery Science and Technology,
_x2192-6204
505 0 _aRNA Interference Pathways and Therapeutic Exploitation RNA Interference -- Synthetic Dicer-Substrate siRNAs as Triggers of RNA Interference -- The Role of MicroRNAs in Natural Tissue Development and Application in Regenerative Medicine -- Intracellular Delivery Considerations for RNAi Therapeutics -- Mucosal Delivery of RNAi Therapeutics -- Nanomedicines for Systemic Delivery of RNAi Therapeutics -- Lipidoids: A Combinatorial Approach to siRNA Delivery -- Polymeric Micelles for siRNA Delivery -- RNAi Therapeutic Delivery by Exosomes -- Aptamer-Mediated siRNA Targeting -- RNAi as Anti-Viral Therapy: The HIV-1 Case -- Genome-Wide RNAi Screen for Identification of Human Host Factors Crucial for Influenza Virus Replication -- The Application of microRNAs in Cancer Diagnostics -- Therapeutic Application of miRNAs in Cancer -- Clinical Development of an Inhalable Anti-RSV siRNA Treatment.
520 _aThe Nobel Prize winning discovery that small interfering RNA can be utilised to control cellular gene expression has propelled the field of RNA interference (RNAi) to the forefront of biomedical science as a potential molecular medicine set to revolutionalise disease treatment.   Harnessing the molecular mechanisms of RNAi and development of delivery technologies is crucial for its transformation into a therapeutic modality, this dependency is the focus of “RNA Interference from Biology to Therapeutics” that gives a comprehensive overview of RNAi biology and state-of-the-art delivery methods relevant to clinical translation of RNAi therapeutics. Key players and shapers in the fields of RNAi and delivery science have been assembled in a single volume to produce a truly unique interdisciplinary text, making it a “must-read” for both students and experts in, and at the interface of, RNAi, pharmaceutical science and medicine. An attractive feature is the “future perspectives” section within each chapter that allows global leaders the opportunity to express their views on the direction the field is moving. Topics covered in the book include miRNA biology and therapeutic exploitation, exosome delivery and clinical translation. “RNA Interference from Biology to Therapeutics” is an up-to-the-minute, highly informative and invaluable text for those actively involved or interested in this fascinating and high-impact field.
650 0 _aMedicine.
650 0 _aPharmaceutical technology.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aPharmaceutical Sciences/Technology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461447436
830 0 _aAdvances in Delivery Science and Technology,
_x2192-6204
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-4744-3
912 _aZDB-2-SBL
999 _c95215
_d95215