| 000 | 03032nam a22004695i 4500 | ||
|---|---|---|---|
| 001 | 978-1-4614-4741-2 | ||
| 003 | DE-He213 | ||
| 005 | 20140220082816.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 121206s2013 xxu| s |||| 0|eng d | ||
| 020 |
_a9781461447412 _9978-1-4614-4741-2 |
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| 024 | 7 |
_a10.1007/978-1-4614-4741-2 _2doi |
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| 050 | 4 | _aRC261-271 | |
| 072 | 7 |
_aMJCL _2bicssc |
|
| 072 | 7 |
_aMED062000 _2bisacsh |
|
| 082 | 0 | 4 |
_a614.5999 _223 |
| 100 | 1 |
_aPanasci, Lawrence. _eeditor. |
|
| 245 | 1 | 0 |
_aAdvances in DNA Repair in Cancer Therapy _h[electronic resource] / _cedited by Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali. |
| 264 | 1 |
_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013. |
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| 300 |
_aVIII, 312 p. 35 illus., 25 illus. in color. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 490 | 1 |
_aCancer Drug Discovery and Development ; _v72 |
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| 505 | 0 | _aPreface -- Repair of DNA Interstrand Cross-links Produced by Cancer Chemotherapeutic Drugs -- DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy? -- Growth factor receptor signaling, DNA damage response, and cancer cell susceptibility to chemotherapy and relapses -- The relationship between DNA-repair genes, cellular radiosensitivity and the response of tumors and normal tissues to radiotherapy -- Important Roles of ERCC1 in DNA Repair and Targeted Therapy -- The role of BRCA1 and BRCA2 in anticancer drug therapy -- DNA-PK in CLL Chemotherapy -- Poly(ADP) ribose polymerase at the interface of DNA damage signalling and DNA repair -- Cellular protection against the antitumor drug bleomycin -- ATR as a Therapeutic Target -- Telomeres, Telomerase and DNA Damage Response in Cancer Therapy -- RAD51 is a key protein of DNA repair and homologous recombination in humans -- Index. | |
| 520 | _aThis book deals with the emerging role of various DNA repair proteins and the regulatory elements which are implicated in cancer therapy such as DNA cross-linking agents, radiotherapy and bleomycin. The DNA repair genes discussed include those involved in BRCA/Rad51-related homologous recombinational repair, DNA-PK related nonhomologous endjoining and the nucleotide excision repair gene, ERCC1. Moreover, the role of regulatory genes such as PARP, ATR, telomerase, growth factor receptors and downstream kinase signalling is examined. | ||
| 650 | 0 | _aMedicine. | |
| 650 | 0 | _aOncology. | |
| 650 | 1 | 4 | _aBiomedicine. |
| 650 | 2 | 4 | _aCancer Research. |
| 650 | 2 | 4 | _aMolecular Medicine. |
| 700 | 1 |
_aAloyz, Raquel. _eeditor. |
|
| 700 | 1 |
_aAlaoui-Jamali, Moulay. _eeditor. |
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| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9781461447405 |
| 830 | 0 |
_aCancer Drug Discovery and Development ; _v72 |
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| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-1-4614-4741-2 |
| 912 | _aZDB-2-SME | ||
| 999 |
_c95214 _d95214 |
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