000			03839nam a22004695i 4500
001			978-1-4614-4654-5
003			DE-He213
005			20140220082816.0
007			cr nn 008mamaa
008			121116s2013 xxu| s |||| 0|eng d
020			_a9781461446545 _9978-1-4614-4654-5
024	7		_a10.1007/978-1-4614-4654-5 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
100	1		_aKoehn, Frank E. _eeditor.
245	1	0	_aNatural Products and Cancer Drug Discovery _h[electronic resource] / _cedited by Frank E. Koehn.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013.
300			_aXII, 244 p. 94 illus., 17 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aCancer Drug Discovery and Development
505	0		_aPreface.-  The Impact of Natural Products upon Cancer Chemotherapy -- Identification and development of vascular disrupting agents: Natural products that interfere with tumor growth -- Discodermolide: Past, Present and Future -- HDAC Inhibitors and Other Histone Modifying Natural Products as Emerging Anticancer Agents -- Natural Product Cytotoxins As Payloads For Antibody Drug Conjugates -- Natural Product Scaffolds in Cancer Therapy -- The Role of Genetic Engineering in Natural Product-based Anticancer Drug Discovery -- Accessing Anti-Cancer Natural Products by Plant Cell Culture -- Natural Products as Tools for Discovering New Cancer Targets -- Index.
520			_aNatural products- compounds derived from plants, microbes and marine organisms, have been an unsurpassed source of cancer drugs in the modern era of drug discovery.  The historical record is strong, but what is the current impact of natural  products in the discovery and development of cancer drugs, and importantly what are the prospects for natural products to be a valuable source of  future agents?  This volume attempts to address this question through a series of chapters authored by leading researchers in the field which effectively provide an in-depth view of several high impact areas of natural products cancer research. The volume begins with a focused analysis and rationale for the clinical success  of current natural product anti-cancer drugs. The following chapters then describe new natural product based drugs in three rapidly evolving target classes and modalities- agents which target tumor vasculature, inhibitors of histone deacetylase and other histone modifying enzymes, and  antibody drug conjugates.  Subsequent chapters examine the central role of natural product chemical scaffolds in the genesis of new anti-cancer therapeutics- first via the powerful application of chemical synthesis, and then through the  rapidly emerging fields of biosynthetic engineering and plant cell culture.  The volume concludes with an assessment of the critical role that natural products continue to play in the search for new cancer drug targets.  As the reader makes his or her way through the volume it may become clear that there is strong evidence that natural products will continue to exert a profound positive impact on cancer drug discovery.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aToxicology.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aOncology.
650	2	4	_aPharmacology/Toxicology.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461446538
830		0	_aCancer Drug Discovery and Development
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-4654-5
912			_aZDB-2-SME
999			_c95194 _d95194