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020 _a9781461443704
_9978-1-4614-4370-4
024 7 _a10.1007/978-1-4614-4370-4
_2doi
050 4 _aQH505
072 7 _aPHVN
_2bicssc
072 7 _aPHVD
_2bicssc
072 7 _aSCI009000
_2bisacsh
082 0 4 _a571.4
_223
100 1 _aThiriet, Marc.
_eauthor.
245 1 0 _aIntracellular Signaling Mediators in the Circulatory and Ventilatory Systems
_h[electronic resource] /
_cby Marc Thiriet.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aXV, 1064 p. 31 illus.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aBiomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems,
_x2193-1682 ;
_v4
505 0 _a1. Introduction -- 2. Signaling Lipids -- 3. Preamble to Cytoplasmic Protein Kinases -- 4. Cytoplasmic Protein Tyrosine Kinases -- 5. Cytoplasmic Protein Serine/Threonine Kinases -- 6. Dual-Specificity Protein Kinases -- 7. Mitogen-Activated Protein Kinase Module -- 8. Dual-Specificity Protein Kinases -- 9. Guanosine Triphosphatases and Their Regulators -- 10. Other Major Types of Signaling Mediators -- 11. Signaling Pathways -- 12. Conclusion -- References -- List of Currently Used Prefixes and Suffixes -- List of Aliases.-Complementary Lists of Notations -- Index.
520 _aThe volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors.  Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled.  Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction. Reviews signaling pathways in the regulation of circulatory and respiratory function Describes ion and molecular carriers and receptors Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows
650 0 _aPhysics.
650 0 _aCardiology.
650 0 _aBiological models.
650 0 _aHydraulic engineering.
650 0 _aBiomedical engineering.
650 1 4 _aPhysics.
650 2 4 _aBiophysics and Biological Physics.
650 2 4 _aBiomedical Engineering.
650 2 4 _aMathematical and Computational Biology.
650 2 4 _aSystems Biology.
650 2 4 _aEngineering Fluid Dynamics.
650 2 4 _aCardiology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461443698
830 0 _aBiomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems,
_x2193-1682 ;
_v4
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-4370-4
912 _aZDB-2-PHA
999 _c95123
_d95123