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001 978-1-4614-4148-9
003 DE-He213
005 20140220082814.0
007 cr nn 008mamaa
008 120803s2013 xxu| s |||| 0|eng d
020 _a9781461441489
_9978-1-4614-4148-9
024 7 _a10.1007/978-1-4614-4148-9
_2doi
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aMED057000
_2bisacsh
082 0 4 _a612.8
_223
100 1 _aKreipke, Christian W.
_eeditor.
245 1 0 _aCerebral Blood Flow, Metabolism, and Head Trauma
_h[electronic resource] :
_bThe Pathotrajectory of Traumatic Brain Injury /
_cedited by Christian W. Kreipke, Jose A. Rafols.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aX, 169 p. 37 illus., 11 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aHistorical perspectives in understanding traumatic brain injury and in situating disruption in CBF in the pathotrajectory of head trauma -- Situating Cerebral Blood Flow in the Pathotrajectory of Head Trauma -- Modeling of traumatic brain injury and its implications in studying the pathology of repeated mild impacts to the head -- The presence of venous damage and microbleeds in traumatic brain injury and the potential future role of angiographic and perfusion magnetic resonance imaging -- Situating the Endothelin System in the pathotrajectory of TBI-induced changes in haemodynamics -- Age and Sex Differences in Cerebral Blood Flow and Autoregulation after Pediatric Traumatic Brain Injury -- New Frontiers in Clinical Trials Aimed at Improving Outcome Following Traumatic Brain Injury.
520 _aTraumatic brain injury (TBI) has caught the ear of the general public in the last few years in the context of injuries seen both in athletes and the military.  Despite TBI being situated as a critical problem in society for multiple decades, the underlying pathotrajectory of TBI has only recently been truly appreciated.  Only recently has TBI research begun to develop better models of TBI that more closely recapitulate the human condition, make new advances in our ability to image pathophysiological sequelae in the brain following TBI, place a greater emphasis on studying the vascular dysfunction that accompanies head trauma, and, very recently, explore a new understanding of how age and sex can alter outcome to brain injury. While this book was developed to satisfy a wide audience, from patient to caregiver, basic scientist to clinical scientist, the overall goal is to present the most current information known about head trauma and to expose areas where we may be deficient in understanding the nuances of TBI.   In particular, focus will be placed on the largest gap in our knowledge—the influence of cerebral blood flow (CBF) and metabolism in outcome following injury. This volume explores such varied concepts as the influence of CBF in the pathotrajectory of TBI, modeling TBI as a means to understand underlying pathological states associated with brain injury victims, disrupted vasculature following head trauma and advanced imaging techniques, vasoreactive substances underlying disrupted blood flow, the role of age and sex on injury outcome, and the latest pre-clinical rationale for focusing on CBF and strategies to improve blood flow as a means to improve outcome in patients suffering the effects of TBI.  Taken together, the information contained in “Cerebral Blood Flow, Metabolism, and Head Trauma” is designed to both educate and illuminate anyone associated with TBI, with the hopes of stimulating future research.
650 0 _aMedicine.
650 0 _aHuman physiology.
650 0 _aNeurosciences.
650 0 _aPathology.
650 0 _aRehabilitation.
650 0 _aSports medicine.
650 1 4 _aBiomedicine.
650 2 4 _aNeurosciences.
650 2 4 _aHuman Physiology.
650 2 4 _aPathology.
650 2 4 _aSports Medicine.
650 2 4 _aRehabilitation.
650 2 4 _aBiomedicine general.
700 1 _aRafols, Jose A.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461441472
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-4148-9
912 _aZDB-2-SBL
999 _c95075
_d95075