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001 978-1-4614-4051-2
003 DE-He213
005 20140220082813.0
007 cr nn 008mamaa
008 120813s2013 xxu| s |||| 0|eng d
020 _a9781461440512
_9978-1-4614-4051-2
024 7 _a10.1007/978-1-4614-4051-2
_2doi
050 4 _aQR355-502
072 7 _aMMFM
_2bicssc
072 7 _aMED052000
_2bisacsh
082 0 4 _a616.9101
_223
100 1 _aTaylor, Keith.
_eeditor.
245 1 0 _aDiabetes and Viruses
_h[electronic resource] /
_cedited by Keith Taylor, Heikki Hyöty, Antonio Toniolo, Arie J. Zuckerman.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aXVIII, 373 p. 54 illus., 39 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPreface -- Historical Background: Virus Involvement in diabetes -- Historical Background: Autoimmune Diabetes -- Genetics of Type 1 Diabetes -- Non-genetic Factors in the Pathogenesis of Type 1 daibetes -- EMC Virus in Mice -- AZ Enteroviruses in the Mouse Model of Type 1 Diabetes -- Kilham Virus in rats -- Reoviruses in Mice -- Ljungan Virus -- Virus-related Diabetes in Cattle -- Epidemiology of Viruses in Type 1 Diabetes -- Molecular Biology of Enteroviruses -- Laboratory Diagnosiws of Enterovirus Infection -- Enterovirus Immunity and the "Hygeine Hypothesis" -- Enteroviruses in Blood -- Coxsackieviruses and Insulitis -- Viruses in the Pancreas in Diabetes -- Other Possible Diabetogenic Viruses: Rotavirus -- Viruses, Diabetes and Autoimmunity: Studies of Subjects at Genetic Risk for Type 1 Diabetes -- Diabetes and Viruses in the Tropics -- Diabetes and Viruses in Australia and the Pacific -- Fulminant Diabetes in Japan -- Defining Causal Relationship: From Outbreak Workup to Clinical Trial -- The nPOD Research Organization -- Genes, Viruses and Molecular Mimicry -- Innate and Cell-mediated Immunity to Enteroviruses -- Innate Responses to Diabetes-Producing Viruses -- Virus Infection of Human Islets In Vitro -- Virus-Induced Cytokines in Human Islets -- Antibody Enhancement of Enterovirus Infection -- Speculation on Diabetes Prevention -- Viruses as Major Environmental Factors for the Induction of Diabetes -- Sumary and Perspectives -- Index.
520 _aDiabetes, in all of its forms, now constitutes a growing health concern, affecting all segments of the world’s population. There is great interest in the factors which influence its etiology and progression. Among these, a number of viruses feature prominently. Hindered by technological limitations, research into this relationship has hitherto been scarce. Recent advances, however, have opened up the field and there is a burgeoning body of literature on the subject. Unfortunately, this literature has been diffuse and often difficult to access. For the first time, this book compiles the views of many of the world’s experts in the field. It addresses questions, ranging from how viruses may destroy or modify the function of pancreatic islets; to which viruses are the most likely culprits; to whether vaccines or etiologic therapies might be used to prevent virus-induced diabetes. Diabetes and Viruses is the first comprehensive volume on an important and expanding field of research that is of interest to clinicians, healthcare managers, epidemiologists, veterinarians, and basic scientists.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aToxicology.
650 0 _aMedical virology.
650 0 _aEmerging infectious diseases.
650 1 4 _aBiomedicine.
650 2 4 _aVirology.
650 2 4 _aInfectious Diseases.
650 2 4 _aImmunology.
650 2 4 _aPharmacology/Toxicology.
700 1 _aHyöty, Heikki.
_eeditor.
700 1 _aToniolo, Antonio.
_eeditor.
700 1 _aZuckerman, Arie J.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461440505
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-4051-2
912 _aZDB-2-SBL
999 _c95055
_d95055