000 03015nam a22004695i 4500
001 978-1-4614-4009-3
003 DE-He213
005 20140220082813.0
007 cr nn 008mamaa
008 120913s2013 xxu| s |||| 0|eng d
020 _a9781461440093
_9978-1-4614-4009-3
024 7 _a10.1007/978-1-4614-4009-3
_2doi
050 4 _aQH301-705
072 7 _aPSA
_2bicssc
072 7 _aSCI086000
_2bisacsh
072 7 _aSCI064000
_2bisacsh
082 0 4 _a570
_223
100 1 _aLavrik, Inna N.
_eeditor.
245 1 0 _aSystems Biology of Apoptosis
_h[electronic resource] /
_cedited by Inna N. Lavrik.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aXII, 203 p. 52 illus., 34 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPreface -- Modeling formalisms in systems biology of apoptosis -- Systems biology of death receptor-induced apoptosis -- Systematic complexity reduction of signaling models and application to a CD95 signaling model for apoptosis -- Systems Biology of the Mitochondrial Apoptosis Pathway -- Systems biology of cell death in hepatocytes -- Understanding different types of cell death using Systems Biology -- Modeling Single Cells in Systems Biology -- Cytokine-cytokine crosstalk and cell-death decisions -- Genetic and genomic dissection of apoptosis signaling -- Index.
520 _aApoptosis is highly defined programmed cell death, which leads to the elimination of cells. Deregulation of programmed cell death is associated with serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. In recent years, apoptosis has been successfully studied using a systems biology approach. Systems biology is a novel field of science which combines mathematical modeling with experimental data leading to predictions of biological processes. The development of this field in recent years is fascinating. Studies of apoptosis using systems biology have provided novel insights into the quantitative regulation of cell death. In Systems Biology of Apoptosis, contemporary systems biology studies devoted to cell death signaling both from experimental and modeling sides is discussed, as well as a focus on how systems biology helps to understand life/death decisions made in the cell and the development of new approaches to rational treatment strategies.
650 0 _aLife sciences.
650 0 _aMedicine.
650 0 _aBiological models.
650 0 _aCytology.
650 1 4 _aLife Sciences.
650 2 4 _aSystems Biology.
650 2 4 _aApoptosis.
650 2 4 _aBiomedicine general.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461440086
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-4009-3
912 _aZDB-2-SBL
999 _c95047
_d95047