000 03247nam a22004695i 4500
001 978-1-4419-9967-2
003 DE-He213
005 20140220082803.0
007 cr nn 008mamaa
008 120905s2013 xxu| s |||| 0|eng d
020 _a9781441999672
_9978-1-4419-9967-2
024 7 _a10.1007/978-1-4419-9967-2
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aKarpf, Adam R.
_eeditor.
245 1 0 _aEpigenetic Alterations in Oncogenesis
_h[electronic resource] /
_cedited by Adam R. Karpf.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aXV, 348 p. 22 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v754
505 0 _aPreface -- Section I: Epigenetic Marks and Mechanisms -- DNA methyltransferases (DNMTs), DNA damage repair, and cancer -- DNA hypomethylation and hemimethylation in cancer -- Ten Eleven Translocation (TET) Enzymes and 5-hydroxymethylation in Mammalian Development and Cancer -- Altered histone modifications in cancer -- Nucleosome occupancy and gene regulation during tumorigenesis -- Section II: The Impact of Epigenetic Alterations on Cancer Biology -- Epigenetic regulation of miRNAs in cancer -- DNA hypomethylation and activation of germline-specific genes in cancer -- APC and DNA demethylation in cell fate specification and intestinal cancer -- Epigenetic changes during cell transformation -- Epigenetic reprogramming of mesenchymal stem cells -- Section III: Clinical Implications and Analysis Methods -- Environmental toxicants, epigenetics, and cancer -- Blood derived DNA methylation markers of cancer risk -- Epigenetic therapies in MDS and AML -- Epigenetic targeting therapies to overcome chemotherapy resistance -- Methods for cancer epigenome analysis -- Index.
520 _aThe purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means “above” genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known to make a large contribution to various aspects of tumorigenesis. These changes include alterations in global and promoter specific DNA methylation, activating and repressive histone modifications, and changes in higher order chromatin structures. Each of these topics will be covered in this book.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aHuman genetics.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aHuman Genetics.
650 2 4 _aOncology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441999665
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v754
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4419-9967-2
912 _aZDB-2-SBL
999 _c94501
_d94501