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001 978-1-4419-7862-2
003 DE-He213
005 20140220082803.0
007 cr nn 008mamaa
008 130507s2013 xxu| s |||| 0|eng d
020 _a9781441978622
_9978-1-4419-7862-2
024 7 _a10.1007/978-1-4419-7862-2
_2doi
050 4 _aQD96.M3
072 7 _aPNFS
_2bicssc
072 7 _aSCI078000
_2bisacsh
082 0 4 _a543.65
_223
100 1 _aChen, Guodong.
_eeditor.
245 1 0 _aCharacterization of Protein Therapeutics using Mass Spectrometry
_h[electronic resource] /
_cedited by Guodong Chen.
264 1 _aBoston, MA :
_bSpringer US :
_bImprint: Springer,
_c2013.
300 _aX, 404 p. 148 illus., 38 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aCharacterization of Protein Therapeutics by Mass Spectrometry: Recent Developments and Future Directions -- The Use of Mass Spectrometry to Characterize the Metabolism of Peptide Therapeutics -- Quantitative Analysis of Biologics Using Mass Spectrometry -- Maximizing Structural Information from Whole Protein Tandem Mass Spectrometry -- Disulfide Linkages of an Albumin Fusion Protein -- Detailed Structural Characterization of Monoclonal Antibodies -- Application of Protein Mass Spectrometry in Impurity and Degradant Characterization -- Mass Spectrometry Methods to Analyze Higher Order Structure of Protein Therapeutics by Chemical Footprinting -- Aglycosylations Alters Protein Conformation in Antibodies Engineered with Specific Effector Functions Using HDX-MS -- Characterizing Biotherapeutic Protein 3D Structures by Electrospray Ion-Mobility Mass Spectrometry -- Oxford University, Characterization of Assemblies of Proteins by Mass Spectrometry.
520 _aProtein therapeutics’ high efficacy, safety, and ability to treat life-threatening diseases such as cancer, inflammation and genetic disorders have revolutionized modern medicine. In 2012, 200 companies competed in this $90 billion year industry.   In Characterization of Protein Therapeutics using Mass Spectrometry, expert contributors from academia and industry highlight current approaches and future trends. The book discusses mass spectrometry techniques as related to the analysis of protein therapeutics, structural identification strategies and quantitative approaches. The book also covers various studies involving characterization of process related protein drug impurities/degradants, metabolites, PTMs and  higher order structures of protein therapeutics.   General practitioners in pharmaceutical research, specialists in analytical sciences, and graduate students studying mass spectrometry and pharmaceutical sciences will find this book useful because of  the  step-by-step approaches and new strategies to solve challenging problems related to protein therapeutics research and development.
650 0 _aChemistry.
650 0 _aHuman genetics.
650 0 _aPharmaceutical technology.
650 0 _aMass spectrometry.
650 0 _aBiotechnology.
650 0 _aBiochemistry.
650 0 _aSurfaces (Physics).
650 1 4 _aChemistry.
650 2 4 _aMass Spectrometry.
650 2 4 _aProtein Science.
650 2 4 _aPharmaceutical Sciences/Technology.
650 2 4 _aBiotechnology.
650 2 4 _aHuman Genetics.
650 2 4 _aCharacterization and Evaluation of Materials.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441978615
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4419-7862-2
912 _aZDB-2-CMS
999 _c94467
_d94467