000			03219nam a22004695i 4500
001			978-0-85729-209-4
003			DE-He213
005			20140220082759.0
007			cr nn 008mamaa
008			120824s2013 xxk| s |||| 0|eng d
020			_a9780857292094 _9978-0-85729-209-4
024	7		_a10.1007/978-0-85729-209-4 _2doi
050		4	_aRC346-429.2
072		7	_aMJN _2bicssc
072		7	_aMED056000 _2bisacsh
082	0	4	_a616.8 _223
100	1		_aSharma, Pankaj. _eeditor.
245	1	0	_aStroke Genetics _h[electronic resource] / _cedited by Pankaj Sharma, James F Meschia.
264		1	_aLondon : _bSpringer London : _bImprint: Springer, _c2013.
300			_aXX, 320 p. 29 illus., 12 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aIntroduction -- Candidate Gene Association Studies in Stroke -- Genome-Wide Association Studies (GWAS) -- The Genetics of Cerebral Aneurysms and Other Vascular Malformations -- Intracerebral Hemorrhage and Cerebral Amyloid Angiopathy -- Clinicogenetic and Pathologic Characteristics of CADASIL -- Monogenic Disorder: Fabry Disease -- Stroke-like Episodes in Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS) -- Genetics of Sickle Cell Disease and Stroke -- Other Monogenetic Stroke Disorders -- White Matter Disease -- Genetics of Carotid Disease -- Genetics of Cervical Artery Dissection -- Stroke Pharmacogenetics -- Ethical Issues in the Genetics of Complex Disorders.
520			_aOver the last decade there has been a substantial increase in our understanding of the genetic basis of common disorders such as stroke. Stroke Genetics is designed to give the reader an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genome-wide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed.   Stroke Genetics benefits from the contribution of renowned experts from throughout the world who have been intimately involved in unraveling the genetic etiology of stroke. Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.
650		0	_aMedicine.
650		0	_aHuman genetics.
650		0	_aInternal medicine.
650		0	_aNeurology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aNeurology.
650	2	4	_aInternal Medicine.
650	2	4	_aHuman Genetics.
700	1		_aMeschia, James F. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780857292087
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-85729-209-4
912			_aZDB-2-SME
999			_c94226 _d94226