000 02742nam a22004695i 4500
001 978-94-017-8035-3
003 DE-He213
005 20140220082533.0
007 cr nn 008mamaa
008 140106s2014 ne | s |||| 0|eng d
020 _a9789401780353
_9978-94-017-8035-3
024 7 _a10.1007/978-94-017-8035-3
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aRibatti, Domenico.
_eauthor.
245 1 0 _aAngiogenesis and Anti-Angiogenesis in Hematological Malignancies
_h[electronic resource] /
_cby Domenico Ribatti.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2014.
300 _aXI, 114 p. 44 illus., 30 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPreface -- Introduction -- Angiogenesis in multiple myeloma -- Angiogenesis in lymphomas -- Angiogenesis in leukemia -- Antiangiogenesis -- Concluding remarks -- References.
520 _aIt has been generally accepted that angiogenesis is involved in the pathogenesis of hematological malignancies, like acute and chronic leukemia, lymphoma, myelodysplastic syndromes, myeloproliferative neoplasms and multiple myeloma. The extent of angiogenesis in the bone marrow has been correlated with disease burden, prognosis and treatment outcome. Reciprocal positive and negative interactions between tumor cells and bone marrow stromal cells, namely hematopoietic stem cells, fibroblasts, osteoblasts/osteoclasts, endothelial cells, endothelial progenitor cells, T cells, macrophages and mast cells, mediated by an array of cytokines, receptors and adhesion molecules, modulate the angiogenic response in hematological tumors. More recently, it has been emphasized the pro-angiogenic role of the so called “vascular niche”, indicating a site rich in blood vessels where endothelial cells and mural cells such as pericytes and smooth muscle cells create a microenvironment that affects the behavior of several stem and progenitor cells, in hematological malignancies.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aHematology.
650 0 _aLife sciences.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aOncology.
650 2 4 _aHematology.
650 2 4 _aLife Sciences, general.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789401780346
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-017-8035-3
912 _aZDB-2-SBL
999 _c94149
_d94149