000 04163nam a22005055i 4500
001 978-94-007-7569-5
003 DE-He213
005 20140220082532.0
007 cr nn 008mamaa
008 131113s2014 ne | s |||| 0|eng d
020 _a9789400775695
_9978-94-007-7569-5
024 7 _a10.1007/978-94-007-7569-5
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aVassiliou, Vassilios.
_eeditor.
245 1 0 _aBone Metastases
_h[electronic resource] :
_bA translational and Clinical Approach /
_cedited by Vassilios Vassiliou, Edward Chow, Dimitrios Kardamakis.
250 _a2nd ed. 2014.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2014.
300 _aIX, 490 p. 54 illus., 20 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCancer Metastasis - Biology and Treatment,
_x1568-2102 ;
_v21
505 0 _aPreface. I Fundamental Concepts -- Pathophysiology of metastatic bone disease -- Bone metastases: epidemiology, clinical picture, SREs and prognosis -- Pain in bone metastases: types and mechanisms. II Investigations Of Bone Metastases -- Radiological evaluations: radiography, CT, MRI.- Nuclear medicine imaging modalities: bone scintigraphy, PET-CT, SPECT.- Bone turnover markers -- New omics approaches for bone metastases. III Therapeutic Management.- Analgesic treatment for bone mets -- Radiotherapy: external beam and radio-surgery -- Radionuclide therapy -- Bisphosphonates -- New targeted therapies for bone metastases -- Chemotherapy and hormone therapy -- HIFU/Radioablation -- Neuropathic bone metastases -- Spinal cord compression and cauda equina compression -- Pathological and impending fracture -- Re-irradiation -- Bone metastases in elderly patients -- Management of metastatic bone disease in the elderly with bisphosphonates and RANKL inhibitors: effectiveness and safety. IV Assesment of Therapeutic Response -- Radiological and nuclear medicine imaging modalities.- Clinical assessment measures -- Outcome measures in bone metastases clinical trials -- Quality of life in patients suffering from metastatic skeletal disease. V Cost of Managing Metastatic Bone Disease -- Cost effectiveness of treatment modalities for bone metastases -- Index.
520 _aThe second edition of this book serves both as an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume describes the molecular and cellular mechanisms involved in the formation of bone metastases, presents the newer advances made in the understanding of the clinical picture and symptoms of patients, analyses the role of bone markers in research and clinical practice and deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases. Moreover, the use of all available treatment methods, such as radiotherapy, surgery and systemic treatments for the management of patients with metastatic bone disease is discussed in detail. Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for researchers, oncologists, orthopaedic surgeons and clinicians dealing with patients with metastatic bone disease.
650 0 _aMedicine.
650 0 _aOncology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aOncology.
650 2 4 _aBiomedicine general.
650 2 4 _aMedicine/Public Health, general.
700 1 _aChow, Edward.
_eeditor.
700 1 _aKardamakis, Dimitrios.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400775688
830 0 _aCancer Metastasis - Biology and Treatment,
_x1568-2102 ;
_v21
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-7569-5
912 _aZDB-2-SBL
999 _c94067
_d94067