000			04615nam a22004815i 4500
001			978-3-7091-1535-0
003			DE-He213
005			20140220082524.0
007			cr nn 008mamaa
008			130902s2014 au | s |||| 0|eng d
020			_a9783709115350 _9978-3-7091-1535-0
024	7		_a10.1007/978-3-7091-1535-0 _2doi
050		4	_aRD701-811
072		7	_aMNS _2bicssc
072		7	_aMN _2bicssc
072		7	_aMED065000 _2bisacsh
082	0	4	_a617.47 _223
100	1		_aShapiro, Irving M. _eeditor.
245	1	4	_aThe Intervertebral Disc _h[electronic resource] : _bMolecular and Structural Studies of the Disc in Health and Disease / _cedited by Irving M. Shapiro, Makarand V. Risbud.
264		1	_aVienna : _bSpringer Vienna : _bImprint: Springer, _c2014.
300			_aX, 446 p. 130 illus., 42 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aBiomechanical and Molecular Studies of the Intervertebral Disc: Introduction to the Structure, Function and Comparative Anatomy of the Vertebrae and the Intervertebral Disc -- The Intervertebral Disc: Overview of Disc Mechanics -- Development of the Intervertebral Disc -- Proteoglycans of the Intervertebral Disc -- Collagen and Other Proteins of the Nucleus Pulposus, Annulus Fibrosus and Cartilage Endplates -- Microenvironmental Regulation of Cell Function and Extracellular Matrix Synthesis by Disc Cells -- The Effects of Mechanical Forces on Nucleus and Annulus Cells -- The Role of the ADAMTS Proteins in the Intervertebral Disc -- Intervertebral Disc Disease: Pathogenesis and Current Treatment Modalities: Epidemiology of Lumbar Disc Degeneration -- Genetic Basis of Intervertebral Disc Degeneration -- Pathogenesis of Intervertebral Disc Degeneration -- Imaging Modalities for Studying Disc Pathology -- Surgical Indications for Lumbar Degenerative Disease -- Spinal Motion Restoration Devices for the Degenerate Disc -- The Non-Surgical Treatment of Back Pain -- Back Pain and Disc Degeneration: Are They Linked?- Clinical Features and Pathobiology of Chordoma -- Models of Disc Disease and Biological Regeneration: Large Animal Models of Disc Degeneration -- Intervertebral Disc Herniation -- The Sand Rat (Psammomys obesus obesus) Model of Spontaneous, Age-Related Intervertebral Disc Generation -- Use of Knockout and Transgenic Mouse Models in Disc Research -- Intervertebral Disc Culture Models and Their Applications to Study Pathogenesis and Repair -- Use of Stem Cells to Regenerate the Disc -- Gene Therapy Approaches for Disc Regeneration -- Enhancing Disc Repair by Growth Factors and Other Modalities -- Tissue Engineering of the Disc.
520			_aThe intervertebral disc is composed of a complex tissue that separates neighboring vertebrae, permits a wide range of motion, and cushions the high biomechanical forces on the spine. Disc degeneration leads to a loss of function and is often associated with excruciating pain. Written by leading scientists and clinicians, this is the only book in the past fifty years devoted entirely to the study of the intervertebral disc. The first part of the book provides a review of the basic biology of the disc in health and disease. The second part considers strategies for mitigating the effects of disc degeneration and discusses the possibility of engineering replacement tissues. The final section is dedicated to approaches that model normal development, and the elucidation of the pathogenesis of degenerative disc disease using animal, organ and cell culture techniques.  This unique and authoritative book bridges the gap between the basic and clinical sciences; its target audience includes basic scientists, orthopedists, neurologists, rehabilitation and physical therapists, primary care physicians and chiropractors, while it also addresses the needs of graduate students, medical students, interns, fellows, and patients who suffer from disc-related pathologies.
650		0	_aMedicine.
650		0	_aNeurosurgery.
650		0	_aOrthopedics.
650		0	_aOrthopedic surgery.
650	1	4	_aMedicine & Public Health.
650	2	4	_aSurgical Orthopedics.
650	2	4	_aNeurosurgery.
650	2	4	_aOrthopedics.
700	1		_aRisbud, Makarand V. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783709115343
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-7091-1535-0
912			_aZDB-2-SME
999			_c93654 _d93654