000 02976nam a22004935i 4500
001 978-3-7091-1300-4
003 DE-He213
005 20140220082524.0
007 cr nn 008mamaa
008 131125s2014 au | s |||| 0|eng d
020 _a9783709113004
_9978-3-7091-1300-4
024 7 _a10.1007/978-3-7091-1300-4
_2doi
050 4 _aQR180-189.5
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
082 0 4 _a616.079
_223
100 1 _aKlink, Magdalena.
_eeditor.
245 1 0 _aInteraction of Immune and Cancer Cells
_h[electronic resource] /
_cedited by Magdalena Klink.
264 1 _aVienna :
_bSpringer Vienna :
_bImprint: Springer,
_c2014.
300 _aX, 263 p. 21 illus., 17 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aImmune cells within tumor microenvironment -- Tumor-stroma interaction and cancer progression -- The role of tumor associated macrophages (TAMs) in tumor progression -- Dendritic cells dysfunction and tumor progression -- Myeloid-derived suppressor cells (MDSC) and tumor growth -- Tumor-infiltrating lymphocytes and their role in solid tumor progression -- Polymorphonuclear neutrophils and tumor: friend or foe? -- Cancer immunosurveillance and immunoediting -- Adoptive T cell immunotherapy – Perfecting self-defense -- Monoclonal antibodies to CTLA4 with focus on ipilimumab.
520 _aThe tumor environment is a dynamic network that includes cancer cells, immune cells, fibroblasts, endothelial cells, extracellular matrix, cytokines and receptors. The aim of this book is to summarize the role of these components, especially immune cells, in tumor suppression and/or progression and describe in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells. Since immunotherapy is an attractive approach to cancer therapy, this book also provides information on the two main strategies: monoclonal antibodies and adaptive T cell immunotherapy, with a focus on recent human clinical trials. The book provides a state-of-the-art, comprehensive overview of immune cells in cancer and is an indispensable resource for scientists and medical doctors working and/or lecturing in the field of cancer research and immunology.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aImmunology.
650 0 _aVaccines.
650 0 _aCytokines.
650 1 4 _aBiomedicine.
650 2 4 _aImmunology.
650 2 4 _aCancer Research.
650 2 4 _aVaccine.
650 2 4 _aCytokines and Growth Factors.
650 2 4 _aMolecular Medicine.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783709112991
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-7091-1300-4
912 _aZDB-2-SBL
999 _c93650
_d93650