000 03246nam a22005055i 4500
001 978-3-642-45179-9
003 DE-He213
005 20140220082522.0
007 cr nn 008mamaa
008 131218s2014 gw | s |||| 0|eng d
020 _a9783642451799
_9978-3-642-45179-9
024 7 _a10.1007/978-3-642-45179-9
_2doi
050 4 _aQH506
072 7 _aMBGR
_2bicssc
072 7 _aPSD
_2bicssc
072 7 _aSCI049000
_2bisacsh
072 7 _aMED067000
_2bisacsh
082 0 4 _a611.01816
_223
100 1 _aBehl, Christian.
_eauthor.
245 1 0 _aCell Aging: Molecular Mechanisms and Implications for Disease
_h[electronic resource] /
_cby Christian Behl, Christine Ziegler.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2014.
300 _aIX, 108 p. 34 illus., 32 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSpringerBriefs in Molecular Medicine,
_x2197-7925
505 0 _aAging and cell aging: an introduction -- Cell cycle: the life cycle of a cell -- Theories and mechanisms of aging -- Selected age-related disorders.
520 _aAging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.
650 0 _aMedicine.
650 0 _aPathology.
650 0 _aCytology.
650 1 4 _aBiomedicine.
650 2 4 _aMolecular Medicine.
650 2 4 _aCell Biology.
650 2 4 _aPathology.
700 1 _aZiegler, Christine.
_eauthor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642451782
830 0 _aSpringerBriefs in Molecular Medicine,
_x2197-7925
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-45179-9
912 _aZDB-2-SBL
999 _c93528
_d93528