000 03229nam a22005415i 4500
001 978-3-642-41199-1
003 DE-He213
005 20140220082521.0
007 cr nn 008mamaa
008 131128s2014 gw | s |||| 0|eng d
020 _a9783642411991
_9978-3-642-41199-1
024 7 _a10.1007/978-3-642-41199-1
_2doi
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
082 0 4 _a615
_223
100 1 _aGurevich, Vsevolod V.
_eeditor.
245 1 0 _aArrestins - Pharmacology and Therapeutic Potential
_h[electronic resource] /
_cedited by Vsevolod V. Gurevich.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2014.
300 _aVIII, 447 p. 53 illus., 42 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aHandbook of Experimental Pharmacology,
_x0171-2004 ;
_v219
505 0 _aTherapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors -- Arrestin-biased GPCR Agonists -- Arrestin-1 Expression Levels, Rod Function and Health -- Protective Functions of Arrestin-1 in Photoreceptors -- Arrestin-4 and Cone Function -- Enhanced Phosphorylation-independent Arrestins and Gene Therapy -- Targeting Particular Receptors with Redesigned Non-visual Arrestins.- Arrestins binding to clathrin, AP2 and Role in GPCR trafficking -- Arrestins in Ubiquitination and Deubiquitination -- Arrestin Self-association -- Arrestin-dependent Activation of ERK and Src -- Arrestin-dependent Activation of JNK Family Kinases -- Arrestin-Mediated P38 Activation.- Arrestin-dependent PDE Localization -- Arrestins in Cell Migration -- Arrestins in Host-pathogen Interactions -- Arrestin Regulation of Small GTPases -- GPCRs and Arrestins in Airways: Implications for Asthma -- Arrestins as Regulatory Signaling Hubs in Cancer Pathways -- Arrestins in Pain and Anesthesia.
520 _aThis volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.
650 0 _aMedicine.
650 0 _aGene therapy.
650 0 _aToxicology.
650 0 _aBiochemistry.
650 0 _aCell receptors.
650 0 _aCytology.
650 1 4 _aBiomedicine.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aBiochemistry, general.
650 2 4 _aProtein Structure.
650 2 4 _aGene Therapy.
650 2 4 _aCell Physiology.
650 2 4 _aReceptors.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642411984
830 0 _aHandbook of Experimental Pharmacology,
_x0171-2004 ;
_v219
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-41199-1
912 _aZDB-2-SBL
999 _c93477
_d93477