000 03325nam a22005175i 4500
001 978-3-642-40591-4
003 DE-He213
005 20140220082521.0
007 cr nn 008mamaa
008 131022s2014 gw | s |||| 0|eng d
020 _a9783642405914
_9978-3-642-40591-4
024 7 _a10.1007/978-3-642-40591-4
_2doi
050 4 _aQR46
072 7 _aMMFM
_2bicssc
072 7 _aMED052000
_2bisacsh
082 0 4 _a616.9041
_223
100 1 _aHilbi, Hubert.
_eeditor.
245 1 0 _aMolecular Mechanisms in Legionella Pathogenesis
_h[electronic resource] /
_cedited by Hubert Hilbi.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2014.
300 _aX, 295 p. 19 illus., 2 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v376
505 0 _aFrom amoeba to macrophages: exploring the molecular mechanisms of Legionella infection in both hosts -- The Legionella pneumophila two-component regulatory systems that participate in the regulation of Icm/Dot effectors -- Facets of small RNA-mediated regulation in Legionella pneumophila -- Type II secretion and Legionella virulence -- Effector translocation by the Legionella Icm/Dot type IV secretion system -- Modulation of small GTPases by Legionella -- Host lipidation: A mechanism for spatial regulation of Legionella effectors -- Phosphoinositides and the Legionella pathogen vacuole -- Legionella phospholipases implicated in virulence -- Cytotoxic glucosyltransferases of Legionella pneumophila -- Modulation of the ubiquitination machinery by Legionella -- Host signal transduction and protein kinases implicated in Legionella infection -- Mouse models of Legionnaires´ disease.
520 _aLegionnaires’ disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aMicrobiology.
650 0 _aEmerging infectious diseases.
650 0 _aBacteriology.
650 1 4 _aBiomedicine.
650 2 4 _aMedical Microbiology.
650 2 4 _aInfectious Diseases.
650 2 4 _aMolecular Medicine.
650 2 4 _aImmunology.
650 2 4 _aBacteriology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642405907
830 0 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v376
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-40591-4
912 _aZDB-2-SBL
999 _c93432
_d93432