000			03266nam a22004815i 4500
001			978-3-642-40444-3
003			DE-He213
005			20140220082520.0
007			cr nn 008mamaa
008			131018s2014 gw | s |||| 0|eng d
020			_a9783642404443 _9978-3-642-40444-3
024	7		_a10.1007/978-3-642-40444-3 _2doi
050		4	_aQR1-502
072		7	_aPSG _2bicssc
072		7	_aSCI045000 _2bisacsh
082	0	4	_a579 _223
100	1		_aVilla, Tomás G. _eeditor.
245	1	0	_aAntimicrobial Compounds _h[electronic resource] : _bCurrent Strategies and New Alternatives / _cedited by Tomás G. Villa, Patricia Veiga-Crespo.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg : _bImprint: Springer, _c2014.
300			_aXVI, 316 p. 47 illus., 18 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aStrategies for the design and discovery of novel antibiotics using genetic engineering and genome mining -- X-ray and Neutron Scattering Foundations for the Research in Antimicrobials -- Antibacterial, Antiviral and Antifungal Activity of Essential Oils: Mechanisms and Applications -- New antimicrobial agents of plant origin -- Advances in beta-lactam antibiotics -- The Cornerstone of Nucleic Acid-affecting Antibiotics in Bacteria -- Genetic analysis and manipulation of polyene antibiotic gene clusters as a way to produce more effective antifungal compounds -- Enzybiotics: The rush towards prevention and control of multi-resistant bacteria (MRB) -- New cell wall-affecting antifungal antibiotics -- Perspectives in the research on Antimicrobial peptides -- Glycopeptides and bacterial cell walls.
520			_aSince penicillin and salvarsan were discovered, a number of new drugs to combat infectious diseases have been developed, but at the same time, the number of multi-resistant microorganism strains is increasing. Thus, the design of new and effective antibacterial, antiviral and antifungal agents will be a major challenge in the next years. This book reviews the current state-of-the-art in antimicrobial research and discusses new strategies for the design and discovery of novel therapies. Topics covered include the use of genetic engineering, genome mining, manipulation of gene clusters, X-ray and neutron scattering as well as the antimicrobial effects of essential oils, antimicrobial agents of plant origin, beta-lactam antibiotics, antimicrobial peptides, and cell-wall-affecting antifungal antibiotics.
650		0	_aLife sciences.
650		0	_aMicrobiology.
650		0	_aPharmaceutical technology.
650		0	_aMicrobial genetics.
650	1	4	_aLife Sciences.
650	2	4	_aMicrobiology.
650	2	4	_aMedical Microbiology.
650	2	4	_aMicrobial Genetics and Genomics.
650	2	4	_aPharmaceutical Sciences/Technology.
700	1		_aVeiga-Crespo, Patricia. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783642404436
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-642-40444-3
912			_aZDB-2-SBL
999			_c93426 _d93426