000 03835nam a22005175i 4500
001 978-3-642-39796-7
003 DE-He213
005 20140220082519.0
007 cr nn 008mamaa
008 131022s2014 gw | s |||| 0|eng d
020 _a9783642397967
_9978-3-642-39796-7
024 7 _a10.1007/978-3-642-39796-7
_2doi
050 4 _aQD431-431.7
072 7 _aPSBZ
_2bicssc
072 7 _aSCI007000
_2bisacsh
082 0 4 _a572.6
_223
100 1 _aMurakami, Katsuhiko S.
_eeditor.
245 1 0 _aNucleic Acid Polymerases
_h[electronic resource] /
_cedited by Katsuhiko S. Murakami, Michael A. Trakselis.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2014.
300 _aVIII, 342 p. 76 illus., 53 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aNucleic Acids and Molecular Biology,
_x0933-1891 ;
_v30
505 0 _aStructural aspects of mitochondrial ribosome function -- Mechanism and control of protein synthesis in mammalian mitochondria -- Translation in mammalian mitochondria : Order and disorder linked to tRNA and Aminoacyl-tRNA synthetases -- Mitochondrial targeting of RNA and mitochondrial translation in yeast and mammalians -- Mechanisms and control of protein synthesis in yeast mitochondria -- Mitochondrial translation in trypanosomatids -- Translation in mitochondria and apicoplasts in Apicomplexa -- Translation in mitochondria in green alga and higher plants -- Translation in flowering plant chloroplasts -- The chloroplasts as platform for recombinant proteins production.
520 _aThis book provides a review of the multitude of nucleic acid polymerases, including DNA and RNA polymerases from Archea, Bacteria and Eukaryota, mitochondrial and viral polymerases, and other specialized polymerases such as telomerase, template-independent terminal nucleotidyl transferase and RNA self-replication ribozyme. Although many books cover several different types of polymerases, no book so far has attempted to catalog all nucleic acid polymerases. The goal of this book is to be the top reference work for postgraduate students, postdocs, and principle investigators who study polymerases of all varieties. In other words, this book is for polymerase fans by polymerase fans. Nucleic acid polymerases play a fundamental role in genome replication, maintenance, gene expression and regulation. Throughout evolution these enzymes have been pivotal in transforming life towards RNA self-replicating systems as well as into more stable DNA genomes. These enzymes are generally extremely efficient and accurate in RNA transcription and DNA replication and share common kinetic and structural features. How catalysis can be so amazingly fast without loss of specificity is a question that has intrigued researchers for over 60 years. Certain specialized polymerases that play a critical role in cellular metabolism are used for diverse biotechnological applications and are therefore an essential tool for research.
650 0 _aLife sciences.
650 0 _aGene expression.
650 0 _aNucleic acids.
650 0 _aEnzymes.
650 0 _aCytology.
650 1 4 _aLife Sciences.
650 2 4 _aEnzymology.
650 2 4 _aNucleic Acid Chemistry.
650 2 4 _aGene Expression.
650 2 4 _aCell Biology.
700 1 _aTrakselis, Michael A.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642397950
830 0 _aNucleic Acids and Molecular Biology,
_x0933-1891 ;
_v30
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-39796-7
912 _aZDB-2-SBL
999 _c93362
_d93362