000			03675nam a22005055i 4500
001			978-3-642-38765-4
003			DE-He213
005			20140220082518.0
007			cr nn 008mamaa
008			131125s2014 gw | s |||| 0|eng d
020			_a9783642387654 _9978-3-642-38765-4
024	7		_a10.1007/978-3-642-38765-4 _2doi
050		4	_aRL1-803
072		7	_aMJK _2bicssc
072		7	_aMED017000 _2bisacsh
082	0	4	_a616.5 _223
100	1		_aHapple, Rudolf. _eauthor.
245	1	0	_aMosaicism in Human Skin _h[electronic resource] : _bUnderstanding Nevi, Nevoid Skin Disorders, and Cutaneous Neoplasia / _cby Rudolf Happle.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg : _bImprint: Springer, _c2014.
300			_aXIII, 229 p. 232 illus., 208 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aPATTERNS AND MECHANISMS: Mosaicism as a Biological Concept: -- History -- Mosaicism in Plants, Animals, Humans -- Mosaicism Versus Chimerism -- The Mechanisms of Mosaicism -- Genomic Mosaicism of Autosomes -- Epigenetic Mosaicism of autosomes -- Genomic Mosaicism of X Chromosomes -- Epigenetic Mosaicism of X Chromosomes -- The patterns of Mosaicism -- Lines of Blaschko -- Checkerboard Pattern -- Phylloid Pattern -- Patchy Pattern Without Midline Separation -- Lateralization -- Other Patterns, so far Unclassifiable -- MOSAIC SKIN DISORDERS: Nevi -- Melanocytic Nevi -- Other Forms of Pigmentary Mosaicism -- Epidermal Nevi -- Vascular Nevi -- Connective Tissue Nevi -- Nevoid Skin Disorders -- Lyonization (Functional X-Chromosome Mosaicism) in X-Linked Skin Disorders -- Autosomal Non-Nevi -- Neoplastic Skin Lesions -- Benign Tumors -- Malignant Tumors -- CONCLUSION.
520			_aMosaicism is a powerful biologic concept, originally developed from the study of plants and animals, and is the necessary basis for the explanation of numerous human skin disorders.   This lavishly illustrated book presents, for the first time, a comprehensive overview of the strikingly manifold patterns and peculiarities of mosaic skin disorders. It is structured in a straightforward, reader-friendly way that will help the dermatologist to understand the underlying molecular mechanisms of skin disorders in order to further improve the treatment outcome. The first two parts of the book are devoted to the mechanisms and patterns of cutaneous mosaicism, with explanation of genomic and epigenetic mosaicism and description of the six archetypal patterns, including the lines of Blaschko, as well as less well defined or as yet unclassifiable patterns. In the third part, the various mosaic skin disorders are examined in depth, including nevi, allelic and non-allelic didymosis, other binary genodermatoses, mosaic manifestations of autosomal dominant skin disorders, and nevoid skin disorders. The book concludes with a note on neoplastic skin lesions, examining models of tumorigenesis.
650		0	_aMedicine.
650		0	_aHuman genetics.
650		0	_aDermatology.
650		0	_aNeurology.
650		0	_aOphthalmology.
650		0	_aPediatrics.
650	1	4	_aMedicine & Public Health.
650	2	4	_aDermatology.
650	2	4	_aPediatrics.
650	2	4	_aHuman Genetics.
650	2	4	_aNeurology.
650	2	4	_aOphthalmology.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783642387647
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-642-38765-4
912			_aZDB-2-SME
999			_c93271 _d93271