000 04470nam a22005655i 4500
001 978-3-642-38505-6
003 DE-He213
005 20140220082518.0
007 cr nn 008mamaa
008 131021s2014 gw | s |||| 0|eng d
020 _a9783642385056
_9978-3-642-38505-6
024 7 _a10.1007/978-3-642-38505-6
_2doi
050 4 _aQH301-705
072 7 _aPSA
_2bicssc
072 7 _aSCI086000
_2bisacsh
072 7 _aSCI064000
_2bisacsh
082 0 4 _a570
_223
100 1 _aAon, Miguel A.
_eeditor.
245 1 0 _aSystems Biology of Metabolic and Signaling Networks
_h[electronic resource] :
_bEnergy, Mass and Information Transfer /
_cedited by Miguel A. Aon, Valdur Saks, Uwe Schlattner.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2014.
300 _aX, 375 p. 90 illus., 67 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSpringer Series in Biophysics,
_x0932-2353 ;
_v16
505 0 _aI Introduction -- From Physiology, Genomes, Systems and Self-Organization to Systems Biology: The Historical Roots of a 21st Century Approach to Complexity -- Systems Biology of Networks: The Riddle and the Challenge -- II Systems Biology of Signaling Networks -- Micrornas and Robustness In Biological Regulatory Networks. A Generic Approach with Applications at Different Levels: Physiologic, Metabolic And Genetic -- Dynamics of Mitochondrial Redox and Energy Networks: Insights from an Experimental-Computational Synergy -- Adenylate Kinase Isoform Network: A Major Hub in Cell Energetics and Metabolic Signaling -- The Control Analysis of Signal Transduction -- III Systems Biology of Cellular Structures and Fluxes -- Moonlighting Function of the Tubulin Cytoskeleton -- Metabolic Dissipative Structures -- Systems Biology Approaches to Cancer Energy Metabolism -- IV Systems Biology of Organ Function -- Network Dynamics in Cardiac Electrophysiology -- Systems Level Regulation of Energy Fluxes via Metabolic Cycles. Role of Creatine and Phosphotransfer Pathways -- V Systems Biology of Microorganisms -- Temporal Partitioning of the Yeast Cellular Network -- Systems Biology and Metabolic Engineering in Bacteria.
520 _aSystems Biology represents a new paradigm aiming at a whole-organism-level understanding of biological phenomena, emphasizing interconnections and functional interrelationships rather than component parts. The study of network properties, and how they control and regulate behavior from the cellular to organism level, constitutes a main focus of Systems Biology. This book addresses from a novel perspective a major unsolved biological problem: understanding how a cell works and what goes wrong in pathology. The task undertaken by the authors is in equal parts conceptual and methodological, integrative and analytical, experimental and theoretical, qualitative and quantitative, didactic and comprehensive. Essentially, they unravel the spatio-temporal unfolding of interacting mass-energy and information networks at the cellular and organ levels, as well as its modulation through activation or repression by signaling networks to produce a certain phenotype or (patho)physiological response. Starting with the historical roots, in thirteen chapters this work explores the Systems Biology of signaling networks, cellular structures and fluxes, organ and microorganism functions. In doing so, it establishes the basis of a 21st century approach to biological complexity.
650 0 _aLife sciences.
650 0 _aProteomics.
650 0 _aBiological models.
650 0 _aMetabolism.
650 0 _aBiology
_xData processing.
650 1 4 _aLife Sciences.
650 2 4 _aSystems Biology.
650 2 4 _aComputer Appl. in Life Sciences.
650 2 4 _aBiological Networks, Systems Biology.
650 2 4 _aMetabolomics.
650 2 4 _aProteomics.
650 2 4 _aBiophysics and Biological Physics.
700 1 _aSaks, Valdur.
_eeditor.
700 1 _aSchlattner, Uwe.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642385049
830 0 _aSpringer Series in Biophysics,
_x0932-2353 ;
_v16
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-38505-6
912 _aZDB-2-SBL
999 _c93249
_d93249