000 02859nam a22005055i 4500
001 978-3-319-01643-6
003 DE-He213
005 20140220082509.0
007 cr nn 008mamaa
008 131104s2014 gw | s |||| 0|eng d
020 _a9783319016436
_9978-3-319-01643-6
024 7 _a10.1007/978-3-319-01643-6
_2doi
050 4 _aQH505
072 7 _aPHVN
_2bicssc
072 7 _aPHVD
_2bicssc
072 7 _aSCI009000
_2bisacsh
082 0 4 _a571.4
_223
100 1 _aColman, Michael A.
_eauthor.
245 1 0 _aMechanisms of Atrial Arrhythmias
_h[electronic resource] :
_bInsights from the Development of a Biophysically Detailed Model of the Human Atria /
_cby Michael A. Colman.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2014.
300 _aXXII, 256 p. 137 illus., 42 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSpringer Theses, Recognizing Outstanding Ph.D. Research,
_x2190-5053
505 0 _aIntroduction -- Background -- Development of a new model for simulating the electrical action potentials of human atrial myocytes -- Development of a family of regional cell models -- Autonomic regulation and pathophysiological remodelling -- 3D Anatomical Modelling of the Atria -- Pacemaking and autonomic regulation in the 3D sinoatrial node and atria -- Atrial Fibrillation -- Discussion.
520 _aThis thesis describes the development of biophysically detailed computer models of the human atria and torso to study the underlying mechanisms of cardiac diseases, some of the most common causes of morbidity and mortality. This is a cross-disciplinary project, involving fundamentals of cardiac electrophysiology, physics of excitable media, applied mathematics and high performance scientific computing and visualisation.  The author uses computer models to provide insights into the underlying mechanisms of the genesis of atrial fibrillation and develops novel techniques for the monitoring of atrial tachycardia. 
650 0 _aPhysics.
650 0 _aCardiology.
650 0 _aBiology
_xData processing.
650 1 4 _aPhysics.
650 2 4 _aBiophysics and Biological Physics.
650 2 4 _aCardiology.
650 2 4 _aComputer Appl. in Life Sciences.
650 2 4 _aNumerical and Computational Physics.
650 2 4 _aMathematical Applications in the Physical Sciences.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319016429
830 0 _aSpringer Theses, Recognizing Outstanding Ph.D. Research,
_x2190-5053
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-01643-6
912 _aZDB-2-PHA
999 _c92705
_d92705