000 03997nam a22004815i 4500
001 978-3-319-01189-9
003 DE-He213
005 20140220082508.0
007 cr nn 008mamaa
008 131224s2014 gw | s |||| 0|eng d
020 _a9783319011899
_9978-3-319-01189-9
024 7 _a10.1007/978-3-319-01189-9
_2doi
050 4 _aQD71-142
072 7 _aPNF
_2bicssc
072 7 _aSCI013010
_2bisacsh
082 0 4 _a543
_223
100 1 _aGonzález, Zacarías León.
_eauthor.
245 1 0 _aPercutaneous Absorption of UV Filters Contained in Sunscreen Cosmetic Products
_h[electronic resource] :
_bDevelopment of Analytical Methods /
_cby Zacarías León González.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2014.
300 _aXVIII, 216 p. 74 illus., 55 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSpringer Theses, Recognizing Outstanding Ph.D. Research,
_x2190-5053
505 0 _aIntroduction -- Sunscreen Cosmetics: Advantages and Drawbacks -- Development of a Chromatographic Method to Estimate the In Vitro Percutaneous Absorption of Hydrosoluble UV Filters -- Determination of the Unconjugated Forms of Benzophenone-3 and Benzophenone-4 in Urine by Solid-Phase Extraction Coupled to a Liquid Chromatographic System with UV/VIS Detection by Using Autormated Sequential Injection Analysis -- Determination of Benzophenone-3 and Their Metabolites in Urine by Solid-Phase Extraction and Liquid Chromatography Tandem Mass Spectrometry -- Determination of Benzophenone-3 and Its Metabolites in Human Semen by Solid-Phase Extraction and Liquid Chromatography Tandem Mass Spectroscopy -- Eluciation of the In Vitro Biotransformation Products of Ethylhexyl Dimthyl PABA by Chromatographic Techniques Coupled to Mass Spectrometry -- Elucidation of the In Vivo Biotransformation Products of Ethylhexyl Dimethyl PABA By Liquid Chromatographic Techniques with Mass Spectrometry Detectors -- Determination of Ethylhexl Dimethyl PABA and Its Metabolites in Semen by Automated Solid-Phase Extraction and Liquid Chromatography Tandem Mass Spectrometry -- Determination of Methyl Benzylidene Camphor and Its Main Metabolite in Urine by Solid-Phase Extraction and Liquid Chromatography Tandem Mass Spectrometry -- Summary and General Conclusions.
520 _aZacarías León's thesis describes the development and validation of analytical methods to estimate the processes set in motion by percutaneous absorption of UV filters in sunscreen cosmetic products. León describes these methods in both in vitro and non-invasive in vivo methodologies. Currently dermatologists recommend the use of sunscreen products not only under conditions of extreme exposure to the sun but also in daily situations. However the chemical compounds in these products contain may lead to undesired processes and cause induced toxicity, estogenic effects and endocrine activity. León establishes methods to investigate these effects and provides valuable information on the undesired side effects associated with the use of UV filters found in sunscreen products. The work in this thesis has led to a number of publications in renowned analytical chemistry journals.
650 0 _aChemistry.
650 0 _aToxicology.
650 0 _aAnalytical biochemistry.
650 0 _aCytology
_xResearch_xMethodology.
650 1 4 _aChemistry.
650 2 4 _aAnalytical Chemistry.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aBiological Techniques.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319011882
830 0 _aSpringer Theses, Recognizing Outstanding Ph.D. Research,
_x2190-5053
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-01189-9
912 _aZDB-2-CMS
999 _c92604
_d92604