000 03393nam a22004455i 4500
001 978-3-319-01008-3
003 DE-He213
005 20140220082507.0
007 cr nn 008mamaa
008 130924s2014 gw | s |||| 0|eng d
020 _a9783319010083
_9978-3-319-01008-3
024 7 _a10.1007/978-3-319-01008-3
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aOrešič, Matej.
_eeditor.
245 1 2 _aA Systems Biology Approach to Study Metabolic Syndrome
_h[electronic resource] /
_cedited by Matej Orešič, Antonio Vidal-Puig.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2014.
300 _aXIX, 384 p. 47 illus., 23 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aThe metabolic syndrome and its complex pathophysiology -- Systems biology in human health and disease -- The liver in metabolic syndrome -- Role of adipose tissue in the pathogenesis and treatment of metabolic syndrome -- The beta cell in metabolic syndrome -- The skeletal muscle in metabolic syndrome -- The central nervous system in metabolic syndrome -- Lipid metabolism in metabolic syndrome -- Gut microbiota in metabolic syndrome -- Proteomics in the systems-level study of the metabolic syndrome -- Metabolomics in the systems-level study of the metabolic syndrome -- Fluxomics -- In vitro colon model to study metabolic syndrome -- Genome-scale modeling of tissue and cancer metabolism -- Modeling of lipid membranes and lipoproteins -- Computational statistics approaches to study metabolic syndrome -- Towards modeling of metabolic syndrome: Tissue crosstalk in lipid spillover.
520 _aThe aim of this book is to provide the target audience, specifically students of Medicine, Biology, Systems Biology and Bioinformatics, as well as experienced researchers in research fields relevant to metabolic syndrome (MetS) with an overview of the challenges and opportunities in systems biology and how it can be used to tackle MetS. In particular, the aims are: (1) to provide an introduction to the key biological processes involved in the pathophysiology of MetS; (2) through the use of specific examples, provide an introduction to the latest technologies that use a systems biology approach to study MetS; and (3) to give an overview of the mathematical modeling approaches for studying MetS. The clearly written chapters by leading experts in the field provide detailed descriptions crucial for the unique position of this book and its focus on the application of systems biology to tackle specific pathophysiologically relevant aspects of MetS and provide a valuable practical guide to this research community.  
650 0 _aMedicine.
650 0 _aHuman physiology.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aMolecular Medicine.
650 2 4 _aHuman Physiology.
700 1 _aVidal-Puig, Antonio.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319010076
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-01008-3
912 _aZDB-2-SBL
999 _c92570
_d92570