000			03443nam a22005295i 4500
001			978-3-0348-0706-7
003			DE-He213
005			20140220082506.0
007			cr nn 008mamaa
008			131122s2014 sz | s |||| 0|eng d
020			_a9783034807067 _9978-3-0348-0706-7
024	7		_a10.1007/978-3-0348-0706-7 _2doi
050		4	_aRM1-950
072		7	_aMMG _2bicssc
072		7	_aMED071000 _2bisacsh
082	0	4	_a615 _223
100	1		_aBosch, Xavier. _eeditor.
245	1	0	_aDrugs Targeting B-Cells in Autoimmune Diseases _h[electronic resource] / _cedited by Xavier Bosch, Manuel Ramos-Casals, Munther A Khamashta.
264		1	_aBasel : _bSpringer Basel : _bImprint: Springer, _c2014.
300			_aXI, 292 p. 3 illus., 2 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aMilestones in Drug Therapy, _x2296-6056
505	0		_aHistoric outline of the development of drugs targeting B-cells -- Understanding B-cell biology -- Pharmacological effects and mechanisms of action of agents blocking B cells -- Systemic lupus erythematosus: direct B-cell blocking -- Systemic lupus erythematosus: indirect B-cell blocking -- B-cell targeted therapies in rheumatoid arthritis -- B-cell targeted therapies in Primary Sjögren Syndrome -- Targeting B cells in ANCA-associated vasculitis -- B-cell targeted therapies in systemic sclerosis and inflammatory myopathies -- B-cell targeted therapies in cryoglobulinemia -- B-cell targeted therapies in autoimmune cytopenias and thrombosis -- Targeting B cells in neurological autoimmune diseases -- Targeting B cells in other systemic autoimmune diseases -- Safety of B-cell targeted therapies -- The future potential of biosimilars targeting B-cells.
520			_aThis book provides a detailed overview of B-cell directed therapies in patients with rheumatic and systemic autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, ANCA-associated vasculitis and cryoglobulinemia. Organ-specific autoimmune diseases are discussed with respect to the use of B-cell directed therapies in neurological autoimmune diseases and autoimmune cytopenias. Situations in which B-cell targeted therapy may be indicated are identified, thereby offering comprehensive support for therapeutic decisions on the basis of the latest published evidence. The book also offers a valuable reference tool for rheumatologists, internists, nephrologists, immunologists, and all specialists involved in the multidisciplinary care of patients with rheumatic and systemic autoimmune diseases.
650		0	_aMedicine.
650		0	_aImmunology.
650		0	_aToxicology.
650		0	_aInternal medicine.
650		0	_aRheumatology.
650	1	4	_aBiomedicine.
650	2	4	_aPharmacology/Toxicology.
650	2	4	_aImmunology.
650	2	4	_aRheumatology.
650	2	4	_aInternal Medicine.
700	1		_aRamos-Casals, Manuel. _eeditor.
700	1		_aKhamashta, Munther A. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783034807050
830		0	_aMilestones in Drug Therapy, _x2296-6056
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-0348-0706-7
912			_aZDB-2-SBL
999			_c92446 _d92446