| 000 | 03545nam a22004935i 4500 | ||
|---|---|---|---|
| 001 | 978-1-4899-8002-1 | ||
| 003 | DE-He213 | ||
| 005 | 20140220082505.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 131121s2014 xxu| s |||| 0|eng d | ||
| 020 |
_a9781489980021 _9978-1-4899-8002-1 |
||
| 024 | 7 |
_a10.1007/978-1-4899-8002-1 _2doi |
|
| 050 | 4 | _aRC261-271 | |
| 072 | 7 |
_aMJCL _2bicssc |
|
| 072 | 7 |
_aMED062000 _2bisacsh |
|
| 082 | 0 | 4 |
_a614.5999 _223 |
| 100 | 1 |
_aBrown, Kristy A. _eauthor. |
|
| 245 | 1 | 0 |
_aObesity and Breast Cancer _h[electronic resource] : _bThe Role of Dysregulated Estrogen Metabolism / _cby Kristy A. Brown, Evan R. Simpson. |
| 264 | 1 |
_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2014. |
|
| 300 |
_aIX, 56 p. 9 illus., 7 illus. in color. _bonline resource. |
||
| 336 |
_atext _btxt _2rdacontent |
||
| 337 |
_acomputer _bc _2rdamedia |
||
| 338 |
_aonline resource _bcr _2rdacarrier |
||
| 347 |
_atext file _bPDF _2rda |
||
| 490 | 1 | _aSpringerBriefs in Cancer Research | |
| 505 | 0 | _aIntroduction -- Estrogens, adiposity and the menopause -- The link between obesity and breast cancer: Epidemiological evidence -- Adipose-derived and obesity-related factors and breast cancer -- Estrogen biosynthesis -- Therapies aimed at breaking the linkage between obesity and breast cancer -- Conclusions. | |
| 520 | _aObesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters. Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer. Aromatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in the bone and brain, respectively. Novel therapies, such as those employed to treat obesity-associated disease, including anti-diabetics, may prove successful at inhibiting aromatase specifically within the breast. This SpringerBrief will explore all of these issues in depth and the authors are in a unique position to write about this topic, having extensive experience in the field of aromatase research. | ||
| 650 | 0 | _aMedicine. | |
| 650 | 0 | _aOncology. | |
| 650 | 0 | _aMetabolic diseases. | |
| 650 | 0 | _aEnzymes. | |
| 650 | 1 | 4 | _aBiomedicine. |
| 650 | 2 | 4 | _aCancer Research. |
| 650 | 2 | 4 | _aMetabolic Diseases. |
| 650 | 2 | 4 | _aEnzymology. |
| 700 | 1 |
_aSimpson, Evan R. _eauthor. |
|
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9781489980014 |
| 830 | 0 | _aSpringerBriefs in Cancer Research | |
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-1-4899-8002-1 |
| 912 | _aZDB-2-SBL | ||
| 999 |
_c92407 _d92407 |
||