000			03248nam a22004935i 4500
001			978-1-4614-9167-5
003			DE-He213
005			20140220082504.0
007			cr nn 008mamaa
008			131108s2014 xxu| s |||| 0|eng d
020			_a9781461491675 _9978-1-4614-9167-5
024	7		_a10.1007/978-1-4614-9167-5 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
100	1		_aMelillo, Giovanni. _eeditor.
245	1	0	_aHypoxia and Cancer _h[electronic resource] : _bBiological Implications and Therapeutic Opportunities / _cedited by Giovanni Melillo.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2014.
300			_aXIV, 363 p. 53 illus., 36 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aCancer Drug Discovery and Development, _x2196-9906
505	0		_aPreface -- Hypoxia and breast cancer metastasis -- Hypoxia and the DNA damage response -- Hypoxia and non-coding RNAs -- Hypoxia and ROS -- Hypoxia and gene expression -- Carbonic anhydrase IX: from biology to therapy -- Imaging the hypoxic tumor microenvironment in preclinical models -- Clinical imaging of hypoxia -- Hypoxia, antiangiogenic therapy and metastasis -- UPR and therapeutic opportunities -- Targeting the hypoxic phenotype -- Marianne Nordsmark: Hypoxia and Radiation therapy -- Pharmacological strategies targeting hypoxia -- Targeting the hypoxic tumor microenvironment -- Clinical exploitation of hypoxia -- Index.
520			_aThe tremendous progress in our understanding of the molecular mechanisms underlying tumor hypoxias has generated a great deal of enthusiasm and provides new opportunities to better understand and target the tumor microenvironment. This book emphasizes how changes in oxygen levels in the tumor microenvironment impact cancer cell biology and provide new opportunities for cancer therapy and the contribution of world renowned experts in tumor hypoxia makes this text an invaluable tool for  understanding how hypoxia impacts the biology, imaging and therapy of human cancers.  Basic and translational scientists alike will find this book to be a source of updated information and an opportunity to further strategic thinking in order to better understand and target the complexity of the hypoxic tumor microenvironment. This book is a reference tool for students, scientists and clinicians who are interested in the role of hypoxia in cancer biology and therapy.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aToxicology.
650		0	_aStem cells.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aMolecular Medicine.
650	2	4	_aPharmacology/Toxicology.
650	2	4	_aStem Cells.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461491668
830		0	_aCancer Drug Discovery and Development, _x2196-9906
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-9167-5
912			_aZDB-2-SBL
999			_c92327 _d92327