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001 978-1-4614-8999-3
003 DE-He213
005 20140220082503.0
007 cr nn 008mamaa
008 131029s2014 xxu| s |||| 0|eng d
020 _a9781461489993
_9978-1-4614-8999-3
024 7 _a10.1007/978-1-4614-8999-3
_2doi
050 4 _aR857.M3
072 7 _aTGM
_2bicssc
072 7 _aTCB
_2bicssc
072 7 _aTEC021000
_2bisacsh
072 7 _aSCI009000
_2bisacsh
082 0 4 _a620.11
_223
100 1 _aJones, Lynne C.
_eeditor.
245 1 0 _aMetal-on-Metal Bearings
_h[electronic resource] :
_bA Clinical Practicum /
_cedited by Lynne C. Jones, Warren O. Haggard, A. Seth Greenwald.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2014.
300 _aX, 200 p. 46 illus., 26 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPreface -- Part I: Introduction -- Chapter 1: Overview of Metal-on-Metal Implants -- Chapter 2: Bearing Surfaces for Joint Replacement: New Materials or New Problems? -- Part II: Clinical -- Chapter 3: Outcome Studies for Metal-on-Metal Bearings: What Evidence-Based Medicine Tells Us -- Chapter 4: Metal Reactivity: Its Influence on Primary and Revision Outcomes -- Chapter 5: Are metal ion levels a trigger for surgical intervention? -- Chapter 6: Metal Sensitivity: Is it possible to Determine Clinically? -- Part III: Biology -- Chapter 7: Wound healing, chronic inflammation, and immune responses -- Chapter 8: Benign Responses to Orthopaedic Implants: Really? -- Chapter 9: What does the Histology Tell Us? -- Part IV: Biomechanics -- Chapter 10: Why metal-on-metal -what laboratory tests have shown us -- Chapter 11: What do the Retrievals really tell us? -- Future Directions.- Index.
520 _aThis book addresses the background and significance of the factors potentially influencing the clinical and biological outcomes of metal-on-metal hip implants. Metal-on-metal bearings were introduced and evaluated as an alternative to other bearing couples, particularly metal-on-polyethylene, due to their enhanced wear resistance as determined in laboratory testing. Initially, reports of short-term clinical outcomes were favorable and an increasing number of metal-on-metal prostheses were implanted. Subsequently, isolated case findings describing adverse tissue responses around the articulation became the harbinger of an increasing number of reports describing pseudotumors and other significant lymphocytic-based responses associated with metal-on-metal prostheses. Questions have been raised as to whether this is an implant, design, or patient-specific response. The reasons why some patients have a negative biological response and pathology while others do not remain to be determined, but tens of thousands of patients in the US,  the UK, and around the world are considered to be at risk. Leading researchers and clinicians describe the issues related to the nature of the biological and pathological responses and the protocols that should be followed to determine if an adverse response is occurring. This book is essential reading for researchers, engineers, and orthopaedic surgeons who are involved in the design, evaluation, and implantation of metal-on-metal prostheses. Presents an historical overview of the use of metal-on-metal articulations Collects for the first time the information necessary to assess clinically and biologically relevant patient outcomes Addresses the practical questions that are being raised by surgeons, researchers, and engineers Features contributions by acknowledged leaders in their fields Describes what the clinician needs to know in order to practice evidence-based medicine Projects directions for clinical, biological, and biomechanical research efforts
650 0 _aMedicine.
650 0 _aOrthopedics.
650 0 _aBiomedical engineering.
650 0 _aBiomaterials.
650 0 _aChemistry, inorganic.
650 0 _aMaterials.
650 1 4 _aMaterials Science.
650 2 4 _aBiomaterials.
650 2 4 _aOrthopedics.
650 2 4 _aBiomedical Engineering.
650 2 4 _aMetallic Materials.
650 2 4 _aMolecular Medicine.
650 2 4 _aTribology, Corrosion and Coatings.
700 1 _aHaggard, Warren O.
_eeditor.
700 1 _aGreenwald, A. Seth.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461489986
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-8999-3
912 _aZDB-2-CMS
999 _c92294
_d92294