| 000 | 02760nam a22004935i 4500 | ||
|---|---|---|---|
| 001 | 978-1-4614-8778-4 | ||
| 003 | DE-He213 | ||
| 005 | 20140220082503.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 131128s2014 xxu| s |||| 0|eng d | ||
| 020 |
_a9781461487784 _9978-1-4614-8778-4 |
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| 024 | 7 |
_a10.1007/978-1-4614-8778-4 _2doi |
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| 050 | 4 | _aR-RZ | |
| 072 | 7 |
_aMBGR _2bicssc |
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| 072 | 7 |
_aMED000000 _2bisacsh |
|
| 082 | 0 | 4 |
_a610 _223 |
| 100 | 1 |
_aMaltsev, Natalia. _eeditor. |
|
| 245 | 1 | 0 |
_aSystems Analysis of Human Multigene Disorders _h[electronic resource] / _cedited by Natalia Maltsev, Andrey Rzhetsky, T. Conrad Gilliam. |
| 264 | 1 |
_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2014. |
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| 300 |
_aXIII, 122 p. 12 illus. in color. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
||
| 490 | 1 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v799 |
|
| 505 | 0 | _aWellness and Health Omics Linked to the Environment: the WHOLE approach to personalized medicine -- Characterizing Multi-omic Data in Systems Biology -- High-throughput Translational Medicine: Challenges and Solutions -- Computational approaches for human disease gene prediction and ranking -- A Personalized Treatment for Lung Cancer: Molecular Pathways, Targeted Therapies, and Genomic Characterization -- Index. | |
| 520 | _aUnderstanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementing conventional reductionist biology with systems-level approaches to human heredity and health as systems of interacting genetic, epigenetic, and environmental factors. This integrative approach holds the promise of unveiling yet unexplored levels of molecular organization and biological complexity. It may also hold the key to deciphering the multigene patterns of disease inheritance. | ||
| 650 | 0 | _aMedicine. | |
| 650 | 0 | _aHuman genetics. | |
| 650 | 0 | _aBiological models. | |
| 650 | 1 | 4 | _aBiomedicine. |
| 650 | 2 | 4 | _aBiomedicine general. |
| 650 | 2 | 4 | _aSystems Biology. |
| 650 | 2 | 4 | _aHuman Genetics. |
| 700 | 1 |
_aRzhetsky, Andrey. _eeditor. |
|
| 700 | 1 |
_aGilliam, T. Conrad. _eeditor. |
|
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9781461487777 |
| 830 | 0 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v799 |
|
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-1-4614-8778-4 |
| 912 | _aZDB-2-SBL | ||
| 999 |
_c92245 _d92245 |
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