000 02913nam a22004815i 4500
001 978-1-4614-8624-4
003 DE-He213
005 20140220082502.0
007 cr nn 008mamaa
008 131203s2014 xxu| s |||| 0|eng d
020 _a9781461486244
_9978-1-4614-8624-4
024 7 _a10.1007/978-1-4614-8624-4
_2doi
050 4 _aRB155-155.8
050 4 _aQH431
072 7 _aMFN
_2bicssc
072 7 _aMED107000
_2bisacsh
082 0 4 _a611.01816
_223
082 0 4 _a599.935
_223
100 1 _aWorkman, Jerry L.
_eeditor.
245 1 0 _aFundamentals of Chromatin
_h[electronic resource] /
_cedited by Jerry L. Workman, Susan M. Abmayr.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2014.
300 _aXIII, 587 p. 98 illus., 94 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPreface -- Histone, Nucleosome and Chromatin Structure -- Histone Chaperones in the Assembly and Disassembly of Chromatin -- Chromatin Remodeling Complexes -- Regulating Chromatin by Histone Acetylation -- Histone Methylation in Chromatin Signaling -- Histone Ubiquitylation Control of Gene Expression -- Regulation of Chromatin Structure and Function by PARP-1 and ADP-ribosylation -- Histone phosphorylation and chromatin dynamics -- Reading histone modifications -- Properties and functions of histone variants -- Transcription through Chromatin -- Chromatin remodeling in DNA repair and replication -- Heterochromatin: A Critical Part of the Genome -- Emerging Areas of Chromatin Research -- Index.
520 _aChromatin is the combination of DNA and proteins that make up the genetic material of chromosomes. It is essential for packaging DNA, regulation of gene expression, DNA replication and repair. The audience for this book includes newly established scientists, graduate students and scientists seeking detailed overviews of various aspects of chromatin structure and function to gain entry into this field. The chapters in this book give a strong, updated groundwork about the fundamentals of chromatin which are essential to understand epigenetics. Some the fundamentals that this book covers include the structure and biochemistry of chromatin and the enzyme complexes that manage it.
650 0 _aMedicine.
650 0 _aHuman genetics.
650 0 _aGene expression.
650 1 4 _aBiomedicine.
650 2 4 _aHuman Genetics.
650 2 4 _aBiomedicine general.
650 2 4 _aGene Expression.
700 1 _aAbmayr, Susan M.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461486237
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-8624-4
912 _aZDB-2-SBL
999 _c92210
_d92210