000 04572nam a22004455i 4500
001 978-1-4614-8603-9
003 DE-He213
005 20140220082502.0
007 cr nn 008mamaa
008 131025s2014 xxu| s |||| 0|eng d
020 _a9781461486039
_9978-1-4614-8603-9
024 7 _a10.1007/978-1-4614-8603-9
_2doi
050 4 _aQP34-38
072 7 _aMFG
_2bicssc
072 7 _aMED075000
_2bisacsh
082 0 4 _a612
_223
100 1 _aBrasier, Allan R.
_eeditor.
245 1 0 _aHeterogeneity in Asthma
_h[electronic resource] /
_cedited by Allan R. Brasier.
264 1 _aBoston, MA :
_bSpringer US :
_bImprint: Humana Press,
_c2014.
300 _aXIV, 354 p. 33 illus., 25 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v795
505 0 _aIntroduction: Applications of Translational Science to Clinical Problems -- Section I:  Spectrum of Asthma -- Introduction to spectrum of asthma -- 1. Introduction to Asthma and Phenotyping -- 2. Epidemiology of Asthma -- 3. Heterogeneity of asthma in society -- 4. Allergens and Environmental Association to Asthma -- 5. Current Clinical Diagnostic Tests for Asthma -- 6. Management of Asthma: the current US and European Guidelines -- 7. Community Interventions in Asthma -- 8. Heterogeneity of Response to Therapy -- Section II: Genetics and Genomics in Asthma -- Introduction to genetics and genomics in asthma -- 9. Genetics of Asthma -- 10. Genomics of Asthma -- 11. Epigenetics of Asthma -- Section III: Proteomics, Metabolomics, and Systems Biology of Asthma.-11. Introduction to proteomics, metabolomics and systems biology of asthma -- 12. Overview of Proteomics in Airway Disease -- 13. Metabolomics in Asthma -- 14. Overview on Methods of Sample Preparation -- 15. Measurement of Innate Immunity in the Airway -- 16. Functional Proteomics in Isolated Cells for Steroid Response -- Section IV:   Modeling Complex Data  in Asthma -- Introduction to modeling complex data in asthma -- 17. Biostatistical Analysis and Predictive Modeling in Asthma Phenotype -- 18. Role of Visual Analytics in Asthma Phenotyping and Complex Data Analysis -- Section V: Biobehavioral Determinants  in  Asthma -- Introduction to biobehavioral determinants -- 19. Central Nervous System Influences in Asthma -- 20. Social and Cultural Influences in Asthma Diagnosis and Management.- Section VI: Conclusions and Future Directions -- Summary.
520 _aAsthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants. In this setting, inducible signaling pathways the airway mucosa play a central role in the initiation of airway inflammation through production of antimicrobial peptides (defensins), cytokines, chemokines and arachidonic acid metabolites that coordinate the complex processes of vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial constriction and tissue remodeling.  These signals also are responsible for leukocytic infiltration into the submucosa, T helper-lymphocyte skewing, and allergic sensitization. Currently, it is well appreciated that asthma is a heterogeneous in terms of onset, exacerbants, severity, and treatment response.  Current asthma classification methods are largely descriptive and focus on a single aspect or dimension of the disease.  An active area of investigation on how to collect, use and visualize multidimensional profiling in asthma.  This book will overview multidimensional profiling strategies and visualization approaches for phenotyping asthma.  As an outcome, this work will facilitate the understanding of disease etiology, prognosis and/or therapeutic intervention.   
650 0 _aMedicine.
650 0 _aHuman physiology.
650 1 4 _aBiomedicine.
650 2 4 _aHuman Physiology.
650 2 4 _aMolecular Medicine.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461486022
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v795
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-8603-9
912 _aZDB-2-SBL
999 _c92205
_d92205