000 04232nam a22005055i 4500
001 978-1-4614-7931-4
003 DE-He213
005 20140220082500.0
007 cr nn 008mamaa
008 130808s2014 xxu| s |||| 0|eng d
020 _a9781461479314
_9978-1-4614-7931-4
024 7 _a10.1007/978-1-4614-7931-4
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aEmili, Andrew.
_eeditor.
245 1 0 _aSystems Analysis of Chromatin-Related Protein Complexes in Cancer
_h[electronic resource] /
_cedited by Andrew Emili, Jack Greenblatt, Shoshana Wodak.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2014.
300 _aXI, 316 p. 52 illus., 50 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPreface -- Systematic proteomic analysis of histone demethylating enzymes linked to cancer -- Histone methylating protein complexes in cancer -- Chromatin protein-protein interaction networks linked to cancer -- Structural genomics and drug discovery for chromatin-related protein complexes involved in histone tail recognition -- Transcription factories and global chromatin (enhancer) interactions in cancer -- Long ncRNAs associated with chromatin complexes and their role in cancer -- Familial and somatic mutations of histone modifying enzymes in cancer -- Chromatin regulators arising from RNAi screens of transformed cancer cell lines -- Chromatin complexes in cancer -- Exploring dynamics of chromatin complexes in cancer based on quantitative proteomics -- Regulatory ncRNAs and their targets -- ncRNA regulatory networks in cancer -- Decoding BAF remodelling complexes in cancer -- Mediator/cohesin complex in cancer -- miRNAs targeting chromatin-related protein complexes regulate epigenetic states in cancer -- Polycomb group protein complexes in cancer stem cells -- Genetic interactions between chromatin factors in cancer cell lines -- Chromatin complexes in DNA repair -- Chromatin complexes in chromosome segregation -- Evolution, co-expression and domain architecture of CM complexes linked to cancer -- Index.
520 _aEpigenetic modifications underlie all aspects of human physiology, including stem cell renewal, formation of cell types and tissues. They also underlie  environmental impacts on human health, including aging and diseases like cancer. Consequently, cracking the epigenetic "code" is considered a key challenge in biomedical research. Chromatin structure and function are modified by protein complexes, causing genes to be turned “on” or “off” and controlling other aspects of DNA function. Yet while there has been explosive growth in the epigenetics field, human chromatin-modifying machines have only recently started to be characterized. To meet this challenge, our book explores complementary experimental tracks, pursued by expert international research groups, aimed at the physical and functional characterization of the diverse repertoire of chromatin protein machines  - namely, the "readers, writers and erasers" of epigenomic marks. These studies include the identification of RNA molecules and drugs that interact selectively with components of the chromatin machinery. What makes this book distinctive is its emphasis on the systematic exploration of chromatin protein complexes in the context of human development and disease networks.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aHuman genetics.
650 0 _aProteomics.
650 0 _aBiological models.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aSystems Biology.
650 2 4 _aHuman Genetics.
650 2 4 _aProteomics.
700 1 _aGreenblatt, Jack.
_eeditor.
700 1 _aWodak, Shoshana.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461479307
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-7931-4
912 _aZDB-2-SBL
999 _c92075
_d92075