000 03413nam a22005295i 4500
001 978-1-4614-5915-6
003 DE-He213
005 20140220082458.0
007 cr nn 008mamaa
008 131123s2014 xxu| s |||| 0|eng d
020 _a9781461459156
_9978-1-4614-5915-6
024 7 _a10.1007/978-1-4614-5915-6
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aKoumenis, Constantinos.
_eeditor.
245 1 0 _aTumor Microenvironment and Cellular Stress
_h[electronic resource] :
_bSignaling, Metabolism, Imaging, and Therapeutic Targets /
_cedited by Constantinos Koumenis, Ester Hammond, Amato Giaccia.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2014.
300 _aX, 290 p. 38 illus., 30 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v772
505 0 _aIntroduction -- Hypoxia and metabolism in cancer -- Hypoxia and Regulation of Cancer Cell Stemness -- Hypoxia-mediated metastasis -- Escape Mechanisms from Antiangiogenic Therapy: An Immune Cell’s Perspective -- Hypoxic VDAC1: a potential mitochondrial marker for cancer therapy -- Hypoxia directed drug strategies to target the tumor microenvironment -- Radiotherapy and the Tumor Microenvironment: Mutual Influence and Clinical Implications -- Autophagy and cell death to target cancer cells: exploiting synthetic lethality as cancer therapeutic -- Intratumoral Hypoxia as the Genesis of Genetic Instability and Clinical Prognosis in Prostate Cancer -- miR-210: Fine-Tuning the Hypoxic Response -- The role of complement in tumor growth -- Imaging angiogenesis, inflammation and metastasis in the tumor microenvironment with magnetic resonance imaging -- Index.
520 _aThe collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aHuman physiology.
650 0 _aImmunology.
650 0 _aMicrobiology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aImmunology.
650 2 4 _aHuman Physiology.
650 2 4 _aMedical Microbiology.
700 1 _aHammond, Ester.
_eeditor.
700 1 _aGiaccia, Amato.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461459149
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v772
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-5915-6
912 _aZDB-2-SBL
999 _c91979
_d91979