000 02899nam a22004335i 4500
001 978-1-4471-5553-9
003 DE-He213
005 20140220082456.0
007 cr nn 008mamaa
008 131119s2014 xxk| s |||| 0|eng d
020 _a9781447155539
_9978-1-4471-5553-9
024 7 _a10.1007/978-1-4471-5553-9
_2doi
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
082 0 4 _a615
_223
100 1 _aBurcham, Philip C.
_eauthor.
245 1 3 _aAn Introduction to Toxicology
_h[electronic resource] /
_cby Philip C. Burcham.
264 1 _aLondon :
_bSpringer London :
_bImprint: Springer,
_c2014.
300 _aXVI, 327 p. 93 illus., 1 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aThe Emergence of Modern Toxicology -- Core Concepts in Toxicology -- Toxicokinetics - The Fate of Chemicals within the Body -- Toxicodynamics - How Chemicals Induce Toxicity -- Fightback - Adaptive Responses to Toxicant Exposure -- Target Organ Toxicity: Liver and Kidney -- Chemical Toxicity to the Unborn.- Chemicals and Cancer.- Everyday Toxicology I - Alcohol.- Everyday Toxicology II - Tobacco.      .
520 _a  This book provides a readable introduction to modern toxicology with a particular focus on the mechanisms underlying the induction of toxicity by foreign substances. Since bioactivation is central to many toxic syndromes, special interest is devoted to chemicals that undergo conversion to toxic metabolites that induce toxic effects as diverse as cancer, birth defects and organ injury. The molecular consequences accompanying damage to cellular DNA and proteins is explored together with the relevance of toxicological paradigms to human diseases caused by alcohol and tobacco. The discipline of toxicology has developed rapidly since the thalidomide disaster in the 1960’s as scientists worldwide seek to understand the adverse health effects of human medicines, environmental pollutants, consumer chemicals and industrial reagents. An Introduction to Toxicology is intended to supplement the recommended reading list of undergraduate and graduate programs in toxicology and pharmacology as an enjoyable, accessible primer with illustrations that “unpack” the concepts being discussed in the text.    
650 0 _aMedicine.
650 0 _aToxicology.
650 1 4 _aBiomedicine.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aMolecular Medicine.
650 2 4 _aBiomedicine general.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781447155522
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4471-5553-9
912 _aZDB-2-SBL
999 _c91906
_d91906