000 03289nam a22004095i 4500
001 978-1-4471-5277-4
003 DE-He213
005 20140220082455.0
007 cr nn 008mamaa
008 130807s2014 xxk| s |||| 0|eng d
020 _a9781447152774
_9978-1-4471-5277-4
024 7 _a10.1007/978-1-4471-5277-4
_2doi
050 4 _aRC681-688.2
072 7 _aMJD
_2bicssc
072 7 _aMED010000
_2bisacsh
082 0 4 _a616.12
_223
100 1 _aFurst, Branko.
_eauthor.
245 1 4 _aThe Heart and Circulation
_h[electronic resource] :
_bAn Integrative Model /
_cby Branko Furst.
264 1 _aLondon :
_bSpringer London :
_bImprint: Springer,
_c2014.
300 _aXXIX, 226 p. 70 illus., 43 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPART I – Early Embryo Circulation -- Introduction -- Early Embryo Circulation – Morphologic Features -- The Onset of Circulation -- Hemodynamics of the Early Embryo Circulation -- Flow Patterns in the Early Embryo Circulation -- Heart Vortex Formation -- Is There a Circulation Without a Heart? -- Embryo Heart is not a Peristaltic Pump -- Flow Perturbation Experiments -- Heart Rate Perturbations -- The Heart as Generator of Pressure -- Ventriculo-Vascular Interaction -- A Brief Comparative Phylogeny -- Evolutionary Aspect of the Rhythmical System -- PART II – Mature Circulation -- Functional Morphology of the Heart -- Regulation of Cardiac Output -- Models of the Heart -- Cardiovascular Response during Exercise -- Hemodynamic Effects of Aortic Occlusion -- Increased Pulmonary Flows -- Single Ventricle Physiology -- Blood as an Organ.
520 _aWhat drives the circulation?  In this comprehensive review of existing circulation models, the conventional view that the heart is a pressure-propulsion pump is challenged. The existing models fail to explain an increasing number of observed circulatory phenomena.   A unifying circulation model is proposed in which the blood, responding to metabolic demands of the tissues, is the primary regulator of cardiac output. This new model arises from accumulated clinical and experimental evidence. The heart, rather than being an organ of blood propulsion, assumes a secondary role and generates pressure by impeding the flow of blood. This is supported by examples from the fields of early embryonic circulation, comparative phylogeny, functional morphology, exercise physiology and a range of clinical scenarios.   The Heart and Circulation: An Integrative Model offers a paradigm shift in the understanding of circulatory phenomena. It will become a valuable resource for all those clinicians, researchers, educators and students who, having been confronted with the paradox of the circulation, are looking for a broader interpretation.
650 0 _aMedicine.
650 0 _aCardiology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aCardiology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781447152767
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4471-5277-4
912 _aZDB-2-SME
999 _c91857
_d91857