000 03463nam a22005295i 4500
001 978-0-387-75613-4
003 DE-He213
005 20140220082454.0
007 cr nn 008mamaa
008 131123s2014 xxu| s |||| 0|eng d
020 _a9780387756134
_9978-0-387-75613-4
024 7 _a10.1007/978-0-387-75613-4
_2doi
050 4 _aRC109-216
072 7 _aMJCJ
_2bicssc
072 7 _aMED022090
_2bisacsh
082 0 4 _a616.9
_223
100 1 _aVinks, Alexander A.
_eeditor.
245 1 0 _aFundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics
_h[electronic resource] /
_cedited by Alexander A. Vinks, Hartmut Derendorf, Johan W. Mouton.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2014.
300 _aIX, 466 p. 110 illus., 12 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aForeword -- Section I: Basic Concepts and Principles -- Introduction to Pharmacodynamics and micrbiology -- In vitro and animal PK/PD model -- MIC and breakpoints -- Principles of applied PK/PD modeling -- Population Pk/PD modeling and its applications to antimicrobials -- Drug resistance and Drug-drug combinations -- Section II: Clinical -- Aminoglycosides -- Beta-lactam antibiotics including continuous infusion -- Macrolides -- Glycopeptides -- Quinolones -- Other.-      .
520 _aOver the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development. Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics  is designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader is introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, from basic research to clinical situations.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aMicrobiology.
650 0 _aToxicology.
650 0 _aPublic health.
650 0 _aEmerging infectious diseases.
650 1 4 _aMedicine & Public Health.
650 2 4 _aInfectious Diseases.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aImmunology.
650 2 4 _aMedical Microbiology.
650 2 4 _aPublic Health.
700 1 _aDerendorf, Hartmut.
_eeditor.
700 1 _aMouton, Johan W.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9780387756127
856 4 0 _uhttp://dx.doi.org/10.1007/978-0-387-75613-4
912 _aZDB-2-SME
999 _c91798
_d91798