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001 9781351235709
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008 191207s2020 flu o 000 0 eng d
040 _aOCoLC-P
_beng
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020 _a9781351235693
_qelectronic book
020 _a1351235699
_qelectronic book
020 _a9781351235709
_qelectronic book
020 _a1351235702
_qelectronic book
020 _a9781351235679
_qelectronic book
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020 _a1351235672
_qelectronic book
_qMobipocket
020 _a9781351235686
_qelectronic book
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020 _a1351235680
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020 _z0815376723
020 _z9780815376729
035 _a(OCoLC)1130037913
_z(OCoLC)1129981285
035 _a(OCoLC-P)1130037913
050 4 _aQP356.3
_b.P47 2020
072 7 _aMED
_x004000
_2bisacsh
072 7 _aMED
_x056000
_2bisacsh
072 7 _aMED
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_2bisacsh
072 7 _aMJD
_2bicssc
082 0 4 _a612.8042
_223
100 1 _aPerlmutter, David,
_d1954-
245 1 4 _aThe Microbiome and the Brain /
_cedited by David Perlmutter.
264 1 _aBoca Raton, FL :
_bCRC Press,
_c[2020]
300 _a1 online resource (233 p.)
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
500 _aDescription based upon print version of record.
505 0 _aCover; Half Title; Title Page; Copyright Page; Contents; Editor; List of Contributors; Introduction; Chapter 1: Assessing the Microbiome-Current and Future Technologies and Applications; Methods for Sequencing the Microbiome; 16S rRNA Sequencing; Shotgun Metagenomic Sequencing; Generating Data from Samples; Common Descriptive Analysis Techniques for Microbiome Data; Diversity Analysis; Relative Abundance Plots; Functional Genomics; Critical Appraisal of Microbiome Data; Simple, Community-Level Analyses-16S rRNA Sequencing; Detailed Metagenomic Analyses-Shotgun Metagenomic Sequencing
505 8 _aBacterial Toxins Breaking the Gut and Blood-Brain BarriersThe Role of LPS in the Breakdown of the Blood-Brain Barrier and the Induction of Pathology in the CNS; Correlation of Intestinal Bacterial LPS Antibody with Occludin/Zonulin, S100B and Aquaporin 4; Association of Gram-Negative Bacterial Molecules (LPS, BCdT) with Alzheimer's Disease (AD); Circulating Antibodies against Bacterial Toxins May Become Pathogenic in the Context of BBB Breakdown; Conclusion; References; Chapter 4: The Microbiome-Its Role in Neuroinflammation: The Autism Spectrum Disorder Paradigm
505 8 _aCross Communication between Brain and Gastrointestinal System: The Gut-Brain AxisCombined Gut and Blood-Brain Barriers Defects; ASD as a Prototypical Example of Gut-Brain Axis Dysfunction; CONCLUSION; References; Chapter 5: Nutrition and the Microbiome-Implications for Autism Spectrum Disorder; Introduction; ASD and Microbiota; ASD and Microbial Metabolites; Gastrointestinal Symptoms and ASD; Nutritional Challenges in Children with ASD; Influence of Diet on Microbiota Composition; Interventions Targeting the Microbiota in ASD to Manage Symptoms
505 8 _aPotential Role of Nutrition in the Microbiota-to-Brain Communication in ASDConclusions and Future Directions; References; Chapter 6: Alzheimer's Disease, the Microbiome, and 21st Century Medicine; Looking Forward; References; Chapter 7: Microbial Involvement in Alzheimer's Disease; Introduction: AD and Human Microbiome; Gut Microbiota and Alzheimer's; Impaired Microbiota and Alzheimer's; Human microbiome and risk factors of AD; Targeting Gut Microbiota for AD Interventions; Future Directions; Conclusions; References; Chapter 8: The Role of the Microbiome in Mood; INTRODUCTION
500 _aThe Gut and its Microbiota
520 _aBrain related disorders are among the most challenging health issues of our time. The development of effective therapeutic and preventive strategies for these disorders relies on a comprehensive understanding of the underlying causative mechanisms. And, until recently, these mechanisms have remained somewhat elusive. The newly discovered pivotal role of the intestinal microbiome in brain health, functionality, and resistance to disease is revolutionizing neuroscience. The Microbiome and the Brain, through the contributions of some of the most forward thinking researchers and clinicians in the field, comprehensively reveals the leading edge of our understanding of the fundamental role of gut microbes and their metabolites in a wide array of seemingly diverse brain issues including Alzheimer's disease, autism, multiple sclerosis, and mood disorders. In addition, mechanisms defining these relationships are explored along with a presentation of the state-of-the-art as it relates to interpretation of relevant laboratory assessments. Finally, novel therapeutic opportunities, derived from this exciting science are presented. Readers will learn: The highly validated relationship between alterations of gut microbes and their metabolites, and risk for Alzheimer's disease. The important link between autism and intestinal dysbiosis. Appropriate interpretation of available laboratory assessments of the intestinal microbiome. The potential role of fecal microbial transplant in neurological diseases. The influence of diet and other lifestyle choices on the microbiome as it relates to brain health and functionality.
588 _aOCLC-licensed vendor bibliographic record.
650 7 _aMEDICAL / Alternative Medicine
_2bisacsh
650 7 _aMEDICAL / Neurology
_2bisacsh
650 7 _aMEDICAL / Nutrition
_2bisacsh
650 0 _aBrain
_xMicrobiology.
650 0 _aHuman body
_xMicrobiology.
856 4 0 _3Taylor & Francis
_uhttps://www.taylorfrancis.com/books/9781351235709
856 4 2 _3OCLC metadata license agreement
_uhttp://www.oclc.org/content/dam/oclc/forms/terms/vbrl-201703.pdf
999 _c131143
_d131143