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001 9781003045410
003 FlBoTFG
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006 m o d
007 cr |||||||||||
008 200721s2021 si a go 000 0 eng d
040 _aOCoLC-P
_beng
_erda
_cOCoLC-P
020 _a9781003045410
_qelectronic book
020 _a1003045413
_qelectronic book
020 _a9781000067385
_qelectronic book
020 _a1000067386
_qelectronic book
020 _a9781000067408
_q(EPUB)
020 _a1000067408
_q(EPUB)
020 _a9781000067392
_q(electronic bk. : Mobipocket)
020 _a1000067394
_q(electronic bk. : Mobipocket)
020 _z981487714X
020 _z9789814877145
024 7 _a10.1201/9781003045410
_2doi
035 _a(OCoLC)1196195768
035 _a(OCoLC-P)1196195768
050 4 _aTP248.65.E59
_bP43 2021
072 7 _aMED
_x072000
_2bisacsh
072 7 _aSCI
_x010000
_2bisacsh
072 7 _aSCI
_x013000
_2bisacsh
072 7 _aMQP
_2bicssc
082 0 4 _a660.6/34
_223
245 0 0 _aPharmaceutical Biocatalysis :
_bDrugs, Genetic Diseases, and Epigenetics /
_cedited by Peter Grunwald.
264 1 _aSingapore :
_bJenny Stanford Publishing,
_c[2021]
300 _a1 online resource :
_billustrations (some color)
336 _atext
_2rdacontent
337 _acomputer
_2rdamedia
338 _aonline resource
_2rdacarrier
490 1 _aJenny Stanford Series on Biocatalysis ;
_vvolume 7
505 0 _aCover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- Preface -- Chapter 1: Fermentative Production of Vitamin B6 -- 1.1: Introduction -- 1.2: De novo Synthesis of Vitamin B6 -- 1.3: Control of Vitamin B6 Homeostasis -- 1.4: Engineering Microorganisms for the Production of B6 Vitamers -- 1.5: Novel Routes for Vitamin B6 Biosynthesis and Production -- 1.6: Rational Design and Construction of a Vitamin B6-Producing Bacterium -- 1.7: Alternative Approaches for Enhancing Vitamin B6 Production -- 1.8: Conclusions
505 8 _aChapter 4: Microbial Biotransformations in the Production and Degradation of Fluorinated Pharmaceuticals -- 4.1: Introduction -- 4.2: Fluorinated Natural Products -- 4.3: Production of Fluorinated Antibiotics in Microorganisms -- 4.4: Biological Production of [18F]-Labelled Compounds for PET Analysis -- 4.5: Microorganisms that Enable Fluorinated Drug Design -- 4.6: Production of Fluorinated Drug Metabolites in Microorganisms -- 4.7: Microbial Degradation of Fluorinated Drugs -- 4.8: Future Prospects and Challenges
520 _aVolume 7 of the Jenny Stanford Series on Biocatalysis deals with several different aspects of pharmaceuticals, which include not only various applications of drugs and their metabolism but also natural resources for active pharmaceutical ingredients as well as the removal of pharmaceutical pollution. In detail, novel approaches for developing microbial fermentation processes to produce vitamin B6 using microorganisms are described together with novel routes for vitamin B6 biosynthesis. The other topics discussed are new approaches for producing the successful anticancer drug Taxol from naturally occurring precursors, molecular farming through plant engineering as a cost-effective means to produce therapeutic and prophylactic proteins, and successful screening of potent microorganisms producing L-asparaginase for various chemotherapeutic applications. Furthermore, microbial biotransformations in the production and degradation of fluorinated pharmaceuticals are described. The other chapters inform the reader about the biotransformation of xenobiotics/drugs in living systems, the degradation of pharmaceuticals by white-rot fungi and their ligninolytic enzymes, and the removal of pharmaceutical pollution from municipal sewage using laccase.
588 _aOCLC-licensed vendor bibliographic record.
650 0 _aEnzymes
_xIndustrial applications.
650 0 _aBiocatalysis.
650 0 _aPharmaceutical chemistry.
650 7 _aMEDICAL / Pharmacy
_2bisacsh
650 7 _aSCIENCE / Biotechnology
_2bisacsh
650 7 _aSCIENCE / Chemistry / General
_2bisacsh
700 1 _aGrunwald, Peter,
_d1941-
_eeditor.
856 4 0 _3Taylor & Francis
_uhttps://www.taylorfrancis.com/books/9781003045410
856 4 2 _3OCLC metadata license agreement
_uhttp://www.oclc.org/content/dam/oclc/forms/terms/vbrl-201703.pdf
999 _c129656
_d129656