000 03197cam a2200529Ki 4500
001 9780429353116
003 FlBoTFG
005 20220509193100.0
006 m o d
007 cr cnu---unuuu
008 191120s2019 si o 000 0 eng d
040 _aOCoLC-P
_beng
_erda
_epn
_cOCoLC-P
020 _a9780429353116
_q(electronic bk.)
020 _a0429353111
_q(electronic bk.)
020 _a9781000707441
_q(electronic bk. : Mobipocket)
020 _a100070744X
_q(electronic bk. : Mobipocket)
020 _a9781000707571
_q(electronic bk. : EPUB)
020 _a1000707571
_q(electronic bk. : EPUB)
020 _a9781000707311
_q(electronic bk. : PDF)
020 _a1000707318
_q(electronic bk. : PDF)
020 _z9789814800808
020 _z9814800805
035 _a(OCoLC)1128094396
035 _a(OCoLC-P)1128094396
050 4 _aTP248.E5
072 7 _aMED
_x009000
_2bisacsh
072 7 _aMED
_x058170
_2bisacsh
072 7 _aMED
_x071000
_2bisacsh
072 7 _aTDCW
_2bicssc
082 0 4 _a660.634
_223
245 0 0 _aPharmaceutical biocatalysis :
_bchemoenzymatic synthesis of active pharmaceutical ingredients /
_cedited by Peter Grunwald.
264 1 _aSingapore :
_bJenny Stanford Publishing,
_c2019.
300 _a1 online resource (1 volume.)
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
520 _aThis volume provides an insight into the future strategies for commercial biocatalysis with a focus on sustainable technologies, together with chemoenzymatic and biotechnological approaches to synthesize various types of approved and new active pharmaceutical ingredients (APIs) via proven and latest synthetic routes using single-step biocatalytic or enzyme cascade reactions. Many of these drugs act as enzyme inhibitors, as discussed in a chapter with a variety of examples. The targeted enzymes are involved in diseases such as different cancers, metastatic and infectious diseases, osteoporosis, and cardiovascular disorders. The biocatalysts employed for API synthesis include hydrolytic enzymes, alcohol dehydrogenases, laccases, imine reductases, reductive aminases, peroxygenases, cytochrome P450 enzymes, polyketide synthases, transaminases, and halogenases. Many of them have been improved with respect to their properties by engineering methods. The book discusses the syntheses of drugs, including alkaloids and antibiotics, non-ribosomal peptides, antimalarial and antidiabetic drugs, prenylated xanthones, antioxidants, and many important (chiral) intermediates required for the synthesis of pharmaceuticals.
588 _aOCLC-licensed vendor bibliographic record.
650 0 _aEnzymes
_xIndustrial applications.
650 0 _aBiocatalysis.
650 0 _aPharmaceutical chemistry.
650 7 _aMEDICAL / Biotechnology
_2bisacsh
650 7 _aMEDICAL / Nursing / Pharmacology
_2bisacsh
650 7 _aMEDICAL / Pharmacology
_2bisacsh
700 1 _aGrunwald, Peter,
_d1941-
_eeditor.
856 4 0 _3Taylor & Francis
_uhttps://www.taylorfrancis.com/books/9780429353116
856 4 2 _3OCLC metadata license agreement
_uhttp://www.oclc.org/content/dam/oclc/forms/terms/vbrl-201703.pdf
999 _c129438
_d129438